This article provides a theoretical policy-making model of chemical sunset that gradually substitutes green alternatives for persistent toxic substances within a finite timeframe. The technological inflexibility of these substances is a tough obstacle to a chemical sunset, because a chemical sunset seeks to ultimately stop, within a short period of time, the risky businesses of these substances that are highly entrenched into our society. In wrestling with this obstacle, the intelligent precautionary “polluter pays” principle integrates three policy (...) tools: a “precautionary `polluter pays' principle,” “intelligent trial and error,” and democratic “regulatory negotiation.” It is designed to promote technological pluralism and strong democracy, as well as to create either trust or mutual adjustment among relevant groups. (shrink)

This paper analyzes contemporary political arguments and examines ethical values applied by Islamic leaders in connection with the debate over the Chemical Weapons Convention of 1993. Ethical arguments with roots deep in the history of Islam have played an important role in shaping discussion about the moral status of chemical weapons, the equity of the treaty, and the relationship of both to justified defense of the community. The author closes by considering broader implications for the relationship beween cultural (...) values and international politics today. (shrink)

The philosophical problem of the utility andmeaning of essences for chemistry cannot beresolved by Wittgenstein's principle thatessence cannot explain use, because use isdisplayed in a field of family resemblances.The transition of chemical taxonomy fromvernacular and mystical based terms to theorybased terms stabilized as a unified descriptivetaxonomy, removes chemical discourse from itsconnection with the vernacular. The transitioncan be tracked using the Lockean concepts ofreal and nominal essences, and the changingpriorities between them. Analyzing propertiesdispositionally, initiating a search forgroundings strengthens the (...) case for a logicalasymmetry between descriptive and explanatorydiscourses. Taxonomy is now driven byexplanatory concepts, but not including thosefrom quantum chemistry. (shrink)

The belief in the Darwinian theory of evolution appeared to be shaken when one tried to interpret statements of molecular biology in it. As a consequence there arose a theory of non-Darwinian neutral evolution. The supporters of this theory believe that under natural conditions no factors exist which can distinguish and select organisms on their internal (molecular) structure. In the opinion of these neutralists natural selection cannot in principle control the molecular constitution of organisms. Contrary to the viewpoint of the (...) critics of neutralism it is impossible to admit that nucleic acids, proteins and other biomolecules can evolve without the participation of natural selection. This controversy in contemporary theoretical biology can be solved by integrating the conceptions of molecular ecology with Darwinian theory. Molecular ecology acknowledges the interactions of organisms by means of chemical substances synthesized by them. Such chemical ecological factors play a leading part in the selective stages of biomolecular evolution. These diverse chemical ecological interrelations take place intensively when living beings interact with parasitic microbes. (shrink)

Friedrich Paneth’s conception of “chemical element” has functioned as the official definition adopted by the International Union of Pure and Applied Chemistry since 1923. Paneth maintains a distinction between empirical and “transcendental” concepts of element; furthermore, chemical science requires fluctuation between the two. The origin of the empirical-transcendental split is found in Immanuel Kant’s classic Critique of Pure Reason (1781/1787). The present paper examines Paneth’s foundational concept of element in light of Kant’s attempt, late in life, to revoke (...) key distinctions made in his Critique, including that of regulative and constitutive functions of reason. In a section of his Opus postumum devoted to the “Transition from the Metaphysical Foundations of Natural Science to Physics,” Kant bends his philosophical system to address the newly emerging sciences of matter of his time. Specifically, he tried, without success, to develop the transcendental ground for microscale motions of bodies encountered in physical, electrical and chemical processes. Paneth’s discussion of chemical element does not take the Opus postumum into account, which is why it begins with a rejection of Kant’s rejection (in his earlier writings) of chemistry’s status as science. I make the case that Paneth’s definition of element effectively maintains something very like Kant’s critical separation of regulative and constitutive principles, while a advancing the concept of chemical science. (shrink)

ArgumentHistorians have accorded a privileged status to the analytic ideal of elements as a distinctive marker of “modern” chemistry. Boyle’s and Lavoisier’s have been used to characterize their modernity, which has in turn justified their status as the founding fathers of modern chemistry. It has been difficult, however, to establish a viable connection between these two fathers or the genealogy of their definitions. I argue in this paper that French didactic tradition gave rise to the definition Boyle stated in the (...) Sceptical Chymist, or the analytic/philosophical ideal of elements. He did not endorse the definition he gave, but criticized its lack of analytic rigor and philosophical sophistication. His critique served as a negative heuristic, leading to Nicolas Lemery’s analytic ideal of “chemical principles” as distinct from “natural principles.” Lemery’s definition survived in French didactic tradition, as is evidenced in Macquer’s and Guyton’s textbooks which provided direct precedents for Lavoisier’s analytic ideal of “elements or principles.”. (shrink)

The theory of chemical symbiosis suggests that biological systems started with the collaboration of two polymeric molecules existing in early Earth: nucleic acids and peptides. Chemical symbiosis emerged when RNA-like nucleic acid polymers happened to fold into 3D structures capable to bind amino acids together, forming a proto peptidyl-transferase center. This folding catalyzed the formation of quasi-random small peptides, some of them capable to bind this ribozyme structure back and starting to form an initial layer that would produce (...) the larger subunit of the ribosome by accretion. TCS suggests that there is no chicken-and-egg problem into the emergence of biological systems as RNAs and peptides were of equal importance to the origin of life. Life has initially emerged when these two macromolecules started to interact in molecular symbiosis. Further, we suggest that life evolved into progenotes and cells due to the emergence of new layers of symbiosis. Mutualism is the strongest force in biology, capable to create novelties by emergent principles; on which the whole is bigger than the sum of the parts. TCS aims to apply the Margulian view of biology into the origins of life field. (shrink)

The article concerns five traditionally difficult issues that chemical educators encounter and how they should be resolved. In some cases I propose the examination of necessary and sufficient conditions in order to cast light on the relationships under discussion. The five educational issues are, the notion that a pH value of seven implies a neutral solution of water and vice versa, the use of Le Châtelier’s Principle, the relative occupation and ionization of 4s and 3d orbitals, the explanation of (...) anomalous electronic configurations and the elements that make up group 3 of the periodic table. (shrink)

This highly readable theory of life and its origins offers a non-technical discussion of a chemical perspective on the fundamental organisation of living systems. Essays on the biological and philosophical significance of Ganti's work of thirty years indicate not only its enduring theoretical significance, but also the continuing relevance and heuristic power of Ganti's insights.

Artificial intelligence can be a game changer to address the global challenge of humanity-threatening climate change by fostering sustainable development. Since chemical research and development lay the foundation for innovative products and solutions, this study presents a novel chemical research and development process backed with artificial intelligence and guiding ethical principles to account for both process- and outcome-related sustainability. Particularly in ethically salient contexts, ethical principles have to accompany research and development powered by artificial intelligence to (...) promote social and environmental good and sustainability while preventing any harm for all stakeholders affected. (shrink)

In his Kritik der reinen Vernunft, Kant asserts that laws of nature “carry with them an expression of necessity”. There is, however, widespread interpretive disagreement regarding the nature and source of the necessity of empirical laws of natural sciences in Kant's system. It is especially unclear how chemistry—a science without a clear, straightforward connection to the a priori principles of the understanding—could contain such genuine, empirical laws. Existing accounts of the necessity of causal laws unfortunately fail to illuminate the (...) possibility of non-physical laws. In this paper, I develop an alternative, ‘ideational’ account of natural laws, according to which ideas of reason necessitate the laws of some non-physical sciences. Chemical laws, for instance, are grounded on ideas of the elements, and the chemist aims to reduce her phenomena to these elements via experimentation. Although such ideas are beyond the possibility of experience, their postulation is necessary for the achievement of reason's theoretical ends: the unification and explanation of the cognitions of science. (shrink)

Resistance to the drugs used in the treatment of many infectious diseases is increasing, while microbial infections are being found to be responsible for more life‐threatening diseases than previously thought. Despite a large investment in the invention and application of high‐throughput screening techniques involving miniaturization and automation, and a diverse array of strategies for designing and constructing various chemical libraries, relatively few new drugs have resulted. Natural products, however, have been a major source of drugs for centuries. Since some (...) of them are produced by organisms as a result of selection in favour of improved defense against competing deleterious microorganisms, in principle they would be less likely to incur resistance. Furthermore, the production of those defensive secondary metabolites is inducible because their original function is a response to environmental challenges. Moreover, symbioses, co‐habitation associations between two or more different species of organisms, are universal in nature, and the production of secondary metabolites by symbiotic microbes may be an important adaptation allowing microbes to affect their hosts. Therefore, co‐culture strategies, using combinations of plant cell–pathogenic microbes, plant cell–endophytes (or symbionts), and symbiont–pathogenic microbes, based on the principles of chemical defense and the known mechanisms of organism interactions, may be an efficient general approach in the search for new anti‐microbial drugs. BioEssays 26:808–813, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

A 4-dimensional periodic table of chemical elements is presented. The 120 elements in the n = 8 system are located on vertices of a 4D-cubic lattice and specified by Cartesian coordinates based on the four quantum numbers. Each quantum number is represented by a vector along a different spatial direction in 4D Euclidean space. The 4D PT has a fixed topology governed by Euler–Poincare-type equation and the chemical elements have a fixed connectivity with neighboring elements within the 4D (...) PT. Various geometric transformations by rotations and elongations of vectors enable morphing of one PT to another in a continuum while preserving the 4D topology. The 4D structure exhibits principles of complementarity and zero-cyclic sum in chemical elements. Complementarity enables the extension to n = 9 elements and beyond. The 4D PT of elements extends to isotopes and also to molecules and compounds with the same underlying principles. (shrink)

Two inter-linked theses are defended in this paper. One is the Duhemian theme that a rigid distinction between physical and chemical properties cannot be upheld. Duhem maintained this view not because the latter are reducible to the former, but because if physics is to remain consistent with chemistry it must prove possible to expand it to accommodate new features, and a rigid distinction would be a barrier to this process. The second theme is that naturally occurring isotopic variants of (...) water are in fact distinct substances, and naturally occurring samples of water are mixtures of these substances. For most practical purposes it is convenient to treat protium oxide, deuterium oxide, and so on, as the same chemical substance, but to insist on this as a matter of principle would stand in conflict with the first thesis. (shrink)

Is life a simple result of a conjunction of physico-chemical processes? Can be reduced to a mere juxtaposition of spatially determined events? What epistemology or world-view allows us to comprehend it? Aristotle built a novel philosophical system in which nature is a dynamical totality which is in constant movement. Life is a manifestation of it, and is formed and governed by the psyche. Psyche is the organizational principle of the different biological levels: nutritive, perceptive and intelective. Driesch's crucial experiment (...) provided empirical proof of the principle of life, which he called entelechy. Entelechy is an intensive manifoldness and cannot be comprehended by the usual extensive parameters. The entelechian's own ambiance is duration. This allows the reintroduction of the concept of teleology in the sphere of the living, understood not as a final cause, but as an order born from desire and leading to action. (shrink)

Intra-molecular connectivity (that is, chemical structure) does not emerge from computations based on fundamental quantum-mechanical principles. In order to compute molecular electronic energies (of C 3 H 4 hydrocarbons, for instance) quantum chemists must insert intra-molecular connectivity “by hand.” Some take this as an indication that chemistry cannot be reduced to physics: others consider it as evidence that quantum chemistry needs new logical foundations. Such discussions are generally synchronic rather than diachronic —that is, they neglect ‘historical’ aspects. However, (...) systems of interest to chemists generally are metastable . In many cases chemical systems of a given elemental composition may exist in any one of several different metastable states depending on the history of the system. Molecular structure generally depends on contingent historical circumstances of synthesis and separation, rather than solely or mainly on relative energies of alternative stable states, those energies in turn determined by relationships among components. Chemical structure is usually ‘kinetically-determined’ rather than ‘thermodynamically-determined.’ For instance, cyclical hydrocarbon ring-systems (as in cyclopropene) are produced only in special circumstances. Adequate theoretical treatments must take account of the persistent effects of such contingent historical events whenever they are relevant—as they generally are in chemistry. (shrink)

In the addenda to his Naming and Necessity, Kripke provides an account of how necessary aposteriori statements are possible. In such a case, there is an apriori general principle telling us that it is necessary if true at all. Though straightforward in its broad compass, this account faces two obvious questions in its application: in each case of necessary aposteriori statements, what is the underlying principle and how is it established apriori? I treat these questions with respect to theoretical identity (...) statements concerning chemical substances, such as ‘water is H2OH2O’. I argue that the general principle underlying the necessity of the statements is that if a chemical substance has a certain chemical composition, then it could not have had any other chemical composition. Then I defend the view that the principle is a conceptual truth by providing a novel derivation of it from the theoretical concept of chemical substance with a sufficient level of formal rigor. The logical principles required for the derivation will also be stated and defended. (shrink)

This paper explores the origins of the analytical definition of simple substance, a concept whose central importance in the new chemistry of Lavoisier and his colleagues is now widely recognized. I argue that this notion derived from the practical activities of metallurgists and mineral assayers, and that the theoretical elaboration necessary for the analytical concept to be understood as relevant to chemistry was inspired by the efforts of enlightened rulers in Sweden and Germany to turn chemical science to the (...) benefit of mining—and thus of the various state treasuries. The involvement of chemically-literate mineralogists in the mining industry led them to adopt the principle that analytically-determined composition was a far more essential aspect of minerals than any mere congeries of properties. The same men who pioneered the analytical notion of simple substance also inaugurated the attempt to define a nomenclature for chemistry based exclusively on composition, as determined in the laboratory. -/- . (shrink)

Chemistry is by far the most productive science concerning the number of publications. A closer look at chemical papers reveals that most papers deal with new substances. The rapid growth of chemical knowledge seriously challenges all institutions and individuals concerned with chemistry. Chemistry documentation following the principle of completeness is required to schematize chemical information, which in turn induces a schematization of chemical research. Chemistry education is forced to seek reasonable principles of selectivity, although nobody (...) can have an overview any more. Philosophical evaluation of the growth of chemical knowledge proves that at the same time chemical ‘nonknowledge’ increases more rapidly. An analysis of reasons, why chemists are making new substances at all, shows that the proliferation of new substances is for the most part an end in itself. The present paper finally argues for the need of a rational discourse among chemists on the aims of chemistry. (shrink)

Arthur Clark and Michael Kube–McDowell (“The Triger”, 2000) suggested the sci-fi idea about the direct transformation from a chemical substance to another by the action of a newly physical, “Trigger” field. Karl Brohier, a Nobel Prize winner, who is a dramatic persona in the novel, elaborates a new theory, re-reading and re-writing Pauling’s “The Nature of the Chemical Bond”; according to Brohier: “Information organizes and differentiates energy. It regularizes and stabilizes matter. Information propagates through matter-energy and mediates the (...) interactions of matter-energy.” Dr Horton, his collaborator in the novel replies: “If the universe consists of energy and information, then the Trigger somehow alters the information envelope of certain substances –“. “Alters it, scrambles it, overwhelms it, destabilizes it” Brohier adds. There is a scientific debate whether or how far chemistry is fundamentally reducible to quantum mechanics. Nevertheless, the fact that many essential chemical properties and reactions are at least partly representable in terms of quantum mechanics is doubtless. For the quantum mechanics itself has been reformulated as a theory of a special kind of information, quantum information, chemistry might be in turn interpreted in the same terms. Wave function, the fundamental concept of quantum mechanics, can be equivalently defined as a series of qubits, eventually infinite. A qubit, being defined as the normed superposition of the two orthogonal subspaces of the complex Hilbert space, can be interpreted as a generalization of the standard bit of information as to infinite sets or series. All “forces” in the Standard model, which are furthermore essential for chemical transformations, are groups [U(1),SU(2),SU(3)] of the transformations of the complex Hilbert space and thus, of series of qubits. One can suggest that any chemical substances and changes are fundamentally representable as quantum information and its transformations. If entanglement is interpreted as a physical field, though any group above seems to be unattachable to it, it might be identified as the “Triger field”. It might cause a direct transformation of any chemical substance by from a remote distance. Is this possible in principle? (shrink)

In the 18th century, the concept of ‘affinity’, ‘principle’ and ‘element’ dominated chemical discourse, both inside and outside the laboratory. Although much work has been done on these terms and the methodological commitments which guided their usage, most studies over the past two centuries have concentrated on their application as relevant to Lavoisier's oxygen theory and the new nomenclature. Kim's affinity challenges this historiographical trajectory by looking at several French chemists in the light of their private thoughts, public disputations (...) and communal networks. In doing so, she tells a complex story which points to the methodological and practical importance of industrial and medical chemistry. The following review highlights the advantages and snares of such an approach and makes a few historiographical points along the way. (shrink)

The history of the hydrogen bond provides a good example of the of an important chemical concept. It illustrates the interplay between empirical and theoretical approaches to the problem of delimiting what has proved to be quite an elusive notion, with chemists whittling away at the particular sorts of case with a view to obtaining a precise, unitary concept. Even though there is a return to a more theoretically inspired notion in more recent research, empirical characterisations remain a feature (...) of the report of a Task Group recently set up by the IUPAC to reconsider the definition of the hydrogen bond, and this situation—by no means unusual for chemical concepts and principles—is unlikely to change in the foreseeable future. These developments are reviewed in this paper, which includes an extended discussion of the enormous significance hydrogen bonding has for the philosopher’s standard example of a “natural kind”, water. There is little to suggest a reduction to what philosophers of physics are pleased to call fundamental principles, and the details raise further questions about what essentialists could possibly have in mind when talking about the microscopic essence of water. (shrink)

The first principle of chemical composition is that elements are actually present in their compounds. It is a golden thread running through the history of compositional thinking in chemistry since before the chemical revolution. Opposed to this principle, which I call Actually Present Elements (APE), is the idea that elements are merely potentially present in their compounds: although not actually present, it is possible to recover them. In this paper I follow that golden thread, and then discuss the (...) status of APE itself: is it true? What arguments were there for it, and when? I argue that APE is a metaphysical principle, albeit at a lower level of generality and abstraction than the term ‘metaphysical’ usually suggests. I critically examine a range of different views on how metaphysical principles might be involved in research programmes in empirical science, and conclude by endorsing Elie Zahar’s view that metaphysical principles such as APE are to be found at the very heart of science. Moreover, they can be recipients of empirical support just like other parts of scientific theory. (shrink)

In his celebrated historic-epistemological work Identité et réalité, Émile Meyerson claimed that the scientific conservation principles were first suggested and accepted for philosophical reasons, and only afterwards were submitted to experimental tests. One of the instances he discussed in his book is the principle of mass conservation in chemical reactions. Meyerson pointed out that several authors, from Antiquity to Kant, accepted the idea of quantitative conservation of matter; and Lavoisier himself was strongly influenced by a priori ideas, using (...) this principle instead of attempting to test it. This paper will review Meyerson’s claim and historic evidence, focusing especially the late nineteenth and early twentieth century, when the principle of mass conservation was tested in highly accurate experiments. Instead of confirming the principle, some of those experiments led to the detection of anomalies. Hans Landolt, for instance, noticed that there were some small violations of the principle. He observed mass variations of about 10−6 in chemical reactions produced in hermetically sealed glass tubes. Since Landolt was a famous chemist, his results produced a strong response. Several researchers repeated his experiments, with different results. Landolt himself improved his experiments, with a balance that could detect mass changes of 10−7. After changes of the experimental procedure, the chemical reactions did not show significant mass changes. There was not, however, any “crucial experiment” “proving” that mass was conserved. The observed anomalies were set aside mainly by theoretical reasons, after the discovery of radioactivity and the development of the theory of relativity. (shrink)

The third article of the “Naming game…” series presents the issues of naming elements discovered and synthesized in the twentieth and twenty-first centuries. Based on the source data, the publication time of the names of the last 35 chemical elements was identified. In the case of discoveries from the end of the twentieth century and the beginning of the twenty-first century, the principle was adopted of the priority of information about the synthesis of a new chemical element in (...) scientific journals or conference reports. However, when the same information was published earlier in the news sections of scientific journals, in articles in popular science journals, and (in modern times) on the websites of interested research institutes, such an info is presented as well. It turned out that in some cases this information is very complex as the names of some elements were changed several times and published in different media in the same period. Therefore, this article is an attempt to sort out the issue of first publishing of the names of the last known 35 chemical elements. (shrink)

Antibodies have now been shown to catalyze a variety of chemical transformations, including hydrolytic, concerted, and bimolecular reactions. The inherent chirality of the antibody binding pocket has been exploited to exert precise stereochemical control over their catalyzed reactions. The mechanisms by which antibodies catalyze reactions are not expected to differ in any general way from those of natural enzymes. Antibodies use their binding energy to stabilize species of higher free energy which appear along the reaction coordinate or effect general (...) acid/base catalysis. The advent of catalytic antibodies promises new catalysts that extend the range of catalysis by proteins to chemical transformations that were not required during the evolution of enzymes. (shrink)

The project of chemistry to classify substances and develop techniques for their transformation into other substances rests on assumptions about the means by which compounds are constituted and reconstituted. Robert Boyle not only proposed empirical tests for a metaphysics of material corpuscules, but also a principle for designing experimental procedures in line with that metaphysics. Later chemists added activity concepts to the repertoire. The logic of activity explanations in modern times involves hierarchies of activity concepts, transitions between levels through non-dispositional (...) groundings. Such hierarchies terminate in powerful particulars, such as elementary charged particles. Do these have a fundamental place in the most recent accounts of molecular architecture, stabilities and transformations? However, a close study of the contemporary chemistry of substances transforming reactions discloses a hybrid metaphysics, making use of both the Boylean corpuscles and Faradayan fields. This is illustrated by an analysis of the metaphysics inherent in John Polanyi’s use of “chemoluminescence” to follow the formation of products in chemical reactions. A brief sketch of a resolution of the tension between the two metaphysical schemes is drawn from Niels Bohr’s radical metaphysics extended from the quantum realm proper to chemistry (and perhaps beyond). (shrink)

Fischer’s approach for structure elucidation of linear aldohexoses is still the most widespread alternative in textbooks for carbohydrates. However, in post-Fischer era, a series of remarkable discoveries and inventions were made in different laboratories, and by their use a more comprehensive and coherent strategy for structure elucidation of linear isomeric aldohexoses can be elaborated. Fischer used the exceptional properties of d-mannose for the knowledge of configuration of C-2 and called it the key of the gate to stereochemistry. We bring the (...) evidence that Fischer had an alternative to this monosaccharide, d-idose. Fischer discovered the correct structure of the enantiomers of tartaric acid by pure intuition but Bijvoet proved it experimentally by means of X-rays. Hybridization, a concept taken by L. Pauling from biology, reconciled physics and chemistry concerning the valence of carbon atom and explained the stereochemical picture that had been empirically elaborated by Van’t Hoff and Le Bel. Other chemical transformations of monosaccharides, useful in the elucidation of their structure, have been also discovered or invented in post-Fischer era. (shrink)

Between 1869 and 1871, D. I. Mendeleev, a teacher at the University at St Petersburg published a textbook of general chemistry intended for his students. The title, Principles of Chemistry was typical for the time: it meant that chemistry was no longer an inquiry on the ultimate principles of matter but had become a science firmly established on a few principles derived from experiment.

This paper defends a constructive interpretation of the Critique of Pure Reason, which is built in analogy with an experimental construction that Kant believes to characteristic of chemistry. I also argue for a way to reconcile the methodological perspective of the constructivist method with that of transcendental reflection. I therefore provide a constructive explanation for what Kant describes as being pure reason and the argument of the transcendental deduction. I propose to frame the different perspectives in such a way that (...) the experimental construction is the ratio cognoscendi of pure reason, while pure reason is the ratio essendi of the experimental construction. O’Neill (1989, 2015) is one of the most important scholars that have argued for a constructivist reading of the Critique of pure reason (CPR). In this paper I develop and explore new aspects of this line of interpretation. One of the main criticisms raised against constructivist readings of Kant’s philosophy is an alleged commitment to subjectivism or voluntarism (cf. Kleingeld & Willaschek 2019). This concern led some scholars to rename their position as constitutivist instead (Korsgaard 2009; Sensen 2013, 2017; Formosa 2011). Constitutivism, is intended to be a sort of constructivism capable of avoiding voluntarism. However, it becomes difficult, sometimes, to differentiate between the constitutivist and foundationalist positions, which are based on transcendental reflection and imply a sort of realist perspective on reason. The same preoccupation applies to the constructivist interpretation of the CPR. In order to deal with this issue, the following questions must be addressed: how can constructivism justify the necessity and universality of transcendental principles of pure reason without compromising the normative and procedural aspects of the construction? How to reconcile arguments based on the analysis of representations and faculties with a constructivist procedure? Or even, how may transcendental reflection, as a view of the possibility of a priori cognition, be rendered compatible with a constructive procedure? This paper is divided into three sections, followed by brief final remarks. The first section outlines the main characteristics of constructivism and relates them to Kant’s positions about the nature of philosophy and its method. The second part argues for a type of experimental constructivism that might serve as a guiding analogy to understand the method underlying the CPR. Thirdly, I will show how the transcendental subject and pure reason are derived from this experimental construction. The conclusion briefly points out some advantages of this position. (shrink)

In this article, an argument is made for extending bioethical principles to place-based community and cultural group protections when there are conflicting perspectives on reporting individual results of biomonitoring studies. Bioethical principles of beneficence, nonmaleficence, respect for autonomy, and justice can incorporate participatory decision-making and understandings of the group conditions of individual research participants, particularly for research studies with vulnerable groups. Arguments for and against biomonitoring communication to individual participants are reviewed here. Assessments of risks and benefits of (...) biomonitoring communication can be improved by considering the contextual conditions of cultural groups and place-based communities. Providing participatory decision-making with all stakeholders about biomonitoring communication can provide more fair benefits than adopting a general, prescriptive clinical standard that favors only group report-backs when clinical utility is low and the scientific understandings of low dose exposures of chemical contaminants to humans are still uncertain. (shrink)

Individual research protections provided by bioethical principles can be extended to group protections, particularly for place-based communities and cultural groups who may share a common harm or burden. In this article, an argument is made for the need to consider the group conditions of individual research subjects in the ethics of individual report-backs of human biomonitoring results. Human biomonitoring, the measuring of concentration of chemicals or their metabolites in blood, urine, breast milk, hair, and other biological samples, can provide (...) an assessment of an individual's exposure to a chemical and can integrate exposures from multiple pathways and sources. Biomonitoring studies have been increasing in the past decade for such purposes as measuring the levels of chemicals that are ingested by members of the general population and at what concentrations, to determine if exposure levels are higher in some groups vs. others, to track temporal trends to establish reference ranges for chemical exposures, and to investigate an association with health. (shrink)

Ethics is a branch of philosophy that analyzes right or wrong of an action. Ethics studies all aspect of human activities; which water pollution is one. Water pollution is the emission of waste or chemicals into water bodies at a quantity that is harmful to man and the aquatic organisms. The Effects of water pollution include mass extinction species, decrease in the biodiversity, and scarcity of fresh water. The question to ask is “how can water pollution be ameliorated if not (...) totally eradicated?” Using the method of philosophical analysis, the paper suggests that the implementation of deep ecological principles by policy makers would be abatements and environmental consciousness for the common good of the society. (shrink)

In present day’s sustainable agriculture is relatively a new area which required more attention by scientist/researchers and this one treated as basic need of human survival. In past decades, sustainable agriculture meets environmental and economic goals simultaneously, that’s why this field has received widespread interest. Green Chemistry is described as the ‘‘design of chemical products and processes to eliminate or reduce the use and generation of hazardous substances. Green chemistry mainly based on 12 principles and plays a very (...) important role in environmental protection. For human development sustainable agriculture and green chemistry both are essential. This article discussed 12 proposed principles of sustainable agriculture inspired by existing 12 principles of Green Chemistry. (shrink)

Structure–activity relationship and quantitative SAR are modeling methods largely used in assessing biological properties of chemical substances. QSAR is based on the hypothesis that the chemical structure is responsible for the activity; it follows that similar molecules are expected to have similar properties. Similarity plays an important role in read across, which categorizes molecules primarily on the basis of similarity. Similarity, and chemical similarity too, is a property differently perceived by humans. The various proposed metrics often disagree (...) with human judgment, and no a unique metric for chemical similarity is universally adopted. Researchers argued that categorization is not only explained by similarity but depends as well on abstract knowledge and the task to accomplish. Moreover, similarity cannot be the unique explanation of a categorization, as different perceptual processes take place in category formation. Assuming that similarity judgments are deeply rooted in human knowledge and perception, cognitive sciences contributions are as important as the mathematical considerations of the classical theories. After an excursus in the many views of similarity in philosophy, mathematics, and cognitive science, the paper explores how connectionist systems, which loosely mimic the human cognitive system, could improve similarity-based choices. A case study on building SARs using connectionism and deep neural networks shows the role of similarity in building and explaining those models. A discussion about deep learning for QSAR and as a modeling tool for science concludes the presentation. (shrink)

The precautionary principle is frequently referred to in various momentous decisions affecting human health and the environment. It has been invoked in contexts as diverse as chemicals regulation, regulation of genetically modified organisms, and research into life-extending therapies. Precaution is not an unknown concept in medical contexts. One author even cites the Hippocratic Oath as a parallel to the precautionary principle.

This essay examines the relationship between the precautionary principle and uncertainty factors used by toxicologists to estimate acceptable exposure levels for toxic chemicals from animal experiments. It shows that the adoption of uncertainty factors in the United States in the 1950s can be understood by reference to the precautionary principle, but not by cost-benefit analysis because of a lack of relevant quantitative data at that time. In addition, it argues that uncertainty factors continue to be relevant to efforts to implement (...) the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards. (shrink)

Secretion systems enable bacteria to import and secrete large macromolecules including DNA and proteins. While most components of these systems have been identified, the molecular mechanisms of macromolecular transport remain poorly understood. Recent findings suggest that various bacterial secretion systems make use of the translocation ratchet mechanism for transporting polymers across the cell envelope. Translocation ratchets are powered by chemical potential differences generated by concentration gradients of ions or molecules that are specific to the respective secretion systems. Bacteria employ (...) these potential differences for biasing Brownian motion of the macromolecules within the conduits of the secretion systems. Candidates for this mechanism include DNA import by the type II secretion/type IV pilus system, DNA export by the type IV secretion system, and protein export by the type I secretion system. Here, we propose that these three secretion systems employ different molecular implementations of the translocation ratchet mechanism. Brownian ratchets are often discussed in the context of directed molecular movement. Bacterial secretion systems transport molecules through membranes in a directed fashion. Here, we focus on recent experiments supporting a role of translocation ratchets in the secretion and import of proteins and DNA. (shrink)

A new design principle is discussed for making a sufficiently complex cell for the creation of the first wet artificial life in the laboratory. The current approach is to attempt a minimal cell, which consists of a liposome that contains a minimal metabolic cycle for self-maintenance and self-replication. Given the lack of success with the minimal cell to date, the authors suggest it is possible to take an alternative approach to building the first wet artificial life form that they have (...) called the first cell. In this article, the concept of the first cell versus the minimal cell is discussed. The new design principle is supported by the following observations that are examined and developed from an Origins of Life perspective: That human development shows a U-shaped curve where the skills and developmental patterns of human infants are proficient at the first phase then decline and subsequently recover to a qualitatively better level. A review of spatial temporal dynamics using cellular automata studies shows that complexity generated at both the initial states and the time evolution dynamics can synthesize rich evolutionary processes. A chemical experiment exhibiting self-organizing dynamics results in the emergence of a self-propelling oil droplet that demonstrates the self-sustaining properties of a non-equilibrium state. Finally, the important design question Is life a contingent or deterministic phenomenon? is examined which asks whether a life form is a dynamic product of its surroundings or whether it is the inevitable outcome of prior events, and is discussed making reference to the characteristics of an art installation The Way Things Go. This contemporary masterpiece, which exhibits a long-lasting chain of unrelated causal events, serves as a theoretical model for discussion of evolutionary processes, suggesting that when it comes to designing wet artificial life forms in the laboratory, both contingent and deterministic processes should be taken into account. (shrink)

Dmitri Mendeleev, while not creatively a philosopher of science, nor a student of systematic philosophy, was eminently a philosophical scientist. Concern about the nature and foundations of his science is evident throughout the text and footnotes of the Principles of Chemistry. One has to presume that his conclusions provided him with some direction for “the study of his great generalizations” in chemistry, especially for the greatest fruit of his efforts, the Periodic System of the Elements. At least it is (...) apparent that somehow he acquired a much greater confidence in the feasibility of systemizing extant chemical knowledge than almost any of his contemporaries. (shrink)

Good governance for nanotechnology and nanomaterials is predicated on principles of general good governance. This paper discusses on what lessons we can learn from the oversight of past emerging technologies in formulating these principles. Nanotechnology provides us a valuable opportunity to apply these lessons and a duty to avoid repeating past mistakes. To do that will require mandatory regulation, grounded in precaution, that takes into account the uniqueness of nanomaterials. Moreover, this policy dialogue is not taking place in (...) a vacuum. In applying the lessons of the past, nanotechnology provides a window to renegotiate our public's social contract on chemicals, health, the environment, and risks. Emerging technologies illuminate structural weaknesses, providing a crucial chance to ameliorate lingering regulatory inadequacies and provide much needed updates of existing laws. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to combine the knowledge (...) and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

I recently read through the most recent 24 issues of Environmental Health Perspectives—the National Institutes of Health journal of, among other issues, scientific research into how environmental contaminants impact animal and human health. It is a catalog of horrors from a public health perspective. Fish and frogs with their sex scrambled; deformed frogs with altered hormone levels in their blood; a nearly threefold increase in birth defects among Minnesota farm children exposed to pesticides; 2,4-D exposure reducing hormone levels in men; (...) insignificant levels of four environmental chemicals adding up to a significant dose; a third study reconfirming a 50% sperm decline in U.S. men, 1934–1996; phthalates elevated in the blood of Puerto Rican girls developing breasts before they are 8; some 6,000 chemicals declared candidates for study as hormone disrupters ; children living near incinerators having delayed sexual development; hypospadias linked to organochlorine levels in the blood of mink, otter, and polar bears; and “No living organism may be considered DDT-free.” Nothing definitive, but it all suggests that things are tending in a direction that is perfectly awful. (shrink)