Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

This paper reports a psychological study of human categorization that looked at the procedures used by expert scientists when dealing with puzzling items. Five professional botanists were asked to specify a category from a set of positive and negative instances. The target category in the study was defined by a feature that was unusual, hence situations of uncertainty and puzzlement were generated. Subjects were asked to think aloud while solving the tasks, and their verbal reports were analyzed. A number of (...) problem solving strategies were identified, and subsequently integrated in a model of knowledge‐guided inductive categorization. Our model proposes that expert knowledge influences the subjects' reasoning in more complex ways than suggested by earlier investigations of scientific reasoning. As in previous studies, domain knowledge influenced our subjects' hypothesis generation and testing; but, additionally, it played a central role when subjects revised their hypotheses. (shrink)