Motivated by a characterization of weakly compact cardinals due to Todorcevic, we introduce a new cardinal characteristic, the C-sequence number, which can be seen as a measure of the compactness of a regular uncountable cardinal. We prove a number of ZFC and independence results about the C-sequence number and its relationship with large cardinals, stationary reflection, and square principles. We then introduce and study the more general C-sequence spectrum and uncover some tight connections between the C-sequence spectrum and the strong (...) coloring principle U(. . .), introduced in Part I of this series. (shrink)