Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers of IBE. We re-analyse the nineteenth-century (...) study of inheritance and development (Stanford’s case study) and extend it into the twentieth century, focusing in particular on both classical Mendelian genetics and the studies by Avery et al. on the chemical nature of the hereditary substance. Our extended case studies show the preference of the biological community for a different methodological standard: the vera causa ideal, which requires that purported causes be shown on non-explanatory grounds to exist and be competent to produce their effects. On this basis, we defend a prospective realism about the biological sciences. 1 Introduction2 Stanford on Unconceived Alternatives3 Pangenesis: A Re-analysis4 The Vera Causa Ideal I: Negative Aspect5 Rendering Heredity Accessible6 The Vera Causa Ideal II: Positive Aspect7 Implications for Scientific Realism8 Conclusion. (shrink)

The no-miracles argument for realism and the pessimistic meta-induction for anti-realism pull in opposite directions. Structural Realism---the position that the mathematical structure of mature science reflects reality---relieves this tension.

SummaryenThe main argument for scientific realism is that our present theories in science are so successful empirically that they can't have got that way by chance - instead they must somehow have latched onto the blueprint of the universe. The main argument against scientific realism is that there have been enormously successful theories which were once accepted but are now regarded as false. The central question addressed in this paper is whether there is some reasonable way to have the best (...) of both worlds: to give the argument from scientific revolutions its full weight and yet still adopt some sort of realist attitude towards presently accepted theories in physics and elsewhere. I argue that there is such a way - through structural realism, a position adopted by Poincare, and here elaborated and defended. (shrink)

Conducted almost exclusively at the epistemological level the scientific realism debate often ignores metaphysical niceties. In the face of the scientific realist’s systematic appeal to metaphysical notions like causation and natural kinds the neglect seems dissonant. Chakravartty aspires to overturn it with a bespoke metaphysics for scientific realism. In pursuing this aim, he undrapes a more comprehensive vision of the scientific realist viewpoint, including a distinctive epistemology.

Robustness is a common platitude: hypotheses are better supported with evidence generated by multiple techniques that rely on different background assumptions. Robustness has been put to numerous epistemic tasks, including the demarcation of artifacts from real entities, countering the “experimenter’s regress,” and resolving evidential discordance. Despite the frequency of appeals to robustness, the notion itself has received scant critique. Arguments based on robustness can give incorrect conclusions. More worrying is that although robustness may be valuable in ideal evidential circumstances (i.e., (...) when evidence is concordant), often when a variety of evidence is available from multiple techniques, the evidence is discordant. †To contact the author, please write to: Jacob Stegenga, Department of Philosophy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093; e‐mail: [email protected]. (shrink)

Relying on an analysis of the case of gravitational lensing, Hacking argues for a "modest antirealism" in astronomy. It is shown here that neither his scientific arguments nor his philosophical doctrines imply an antirealist conclusion. An alternative, realistic interpretation of gravitational lensing, and of the nature and history of astronomy more generally, is suggested.

Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers of IBE. We re-analyze the nineteenth-century (...) study of inheritance and development (Stanford’s case study) and extend it into the twentieth century, focusing in particular on both classical Mendelian genetics and the studies by Avery et al. on the chemical nature of the hereditary substance. Our extended case studies show the preference of the biological community for a different methodological standard: the vera causa ideal, which requires that purported causes be shown on non-explanatory grounds to exist and be competent to produce their effects. On this basis, we defend a prospective realism about the biological sciences. (shrink)

In its original form due to Ian Hacking, entity realism postulates a criterion of manipulative success which replaces explanatory virtue as the criterion of justified scientific belief. The article analyses the foundations on which this postulate rests and identifies the conditions on which one can derive a form of entity realism from it. It then develops in detail an extensive class of counterexamples, drawing on the notion of quasi-particles in condensed matter physics. While the phenomena associated with quasi-particles pass the (...) entity realist's criterion of manipulative success, quasi-particles themselves are illusions, and can be seen to be so even on the basis of the largely non-theoretical "home truths" that one must be ready to admit as background knowledge. Hence, Hacking's entity realism is shown to be incoherent. (shrink)

A number of scholars have recently drawn attention to the importance of iteration in scientific research. This paper builds on these previous discussions by drawing a distinction between epistemic and methodological forms of iteration and by clarifying the relationships between them. As defined here, epistemic iteration involves progressive alterations to scientific knowledge claims, whereas methodological iteration refers to an interplay between different modes of research practice. While distinct, these two forms of iteration are related in important ways. Contemporary research on (...) the biological effects of nanomaterials illustrates that methodological iteration can help to “initiate,” “equip,” and “stimulate” epistemic iteration. (shrink)

Why does an object or phenomenon become the subject of scientific inquiry? Why do some of these objects remain provocative, while others fade from center stage? And why do objects sometimes return as the focus of research long after they were once abandoned? Addressing such questions, _Biographies of Scientific Objects_ is about how whole domains of phenomena—dreams, atoms, monsters, culture, society, mortality, centers of gravity, value, cytoplasmic particles, the self, tuberculosis—come into being and sometimes pass away as objects of scientific (...) study. With examples drawn from both the natural and social sciences, and ranging from the sixteenth to the twentieth centuries, this book explores the ways in which scientific objects are both real and historical. Whether discovered or invented, these objects of inquiry broaden and deepen in meaning—growing more "real"—as they become entangled in webs of cultural significance, material practices, and theoretical derivations. Thus their biographies will matter to anyone concerned with the formation of scientific knowledge. Contributors are Jed Z. Buchwald, Lorraine Daston, Rivka Feldhay, Jan Goldstein, Gerard Jorland, Doris Kauffman, Bruno Latour, Theodore M. Porter, Hans-Jörg Rheinberger, Marshall Sahlins, and Peter Wagner. (shrink)

In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things. A central concern of the book is the basic question of how novelty is generated in the empirical sciences. In addressing this question, (...) the author brings French poststructuralist thinking—notably Jacques Derrida’s concepts of “différance” and “historiality”—to bear on the construction of epistemic things. Historiographical perspective shifts from the actors’ minds to their objects of manipulation. These epistemological and historical issues are illuminated in a detailed case study of a particular laboratory, that of the oncologist and biochemist Paul C. Zamecnik and his colleagues, located in a specific setting—the Collis P. Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital of Boston. The author traces how, between 1945 and 1965, this group developed an experimental system for synthesizing proteins in the test tube that put Zamecnik’s research team at the forefront of those who led biochemistry into the era of molecular biology. (shrink)

This book presents the concept of “complementary science” which contributes to scientific knowledge through historical and philosophical investigations. It emphasizes the fact that many simple items of knowledge that we take for granted were actually spectacular achievements obtained only after a great deal of innovative thinking, painstaking experiments, bold conjectures, and serious controversies. Each chapter in the book consists of two parts: a narrative part that states the philosophical puzzle and gives a problem-centred narrative on the historical attempts to solve (...) the puzzle; and the analysis part which provides in-depth analyses of certain scientific, historical, and philosophical aspects of the story. (shrink)

This book offers a philosophy for error-prone humans trying to understand messy systems in the real world.

This 1983 book is a lively and clearly written introduction to the philosophy of natural science, organized around the central theme of scientific realism. It has two parts. 'Representing' deals with the different philosophical accounts of scientific objectivity and the reality of scientific entities. The views of Kuhn, Feyerabend, Lakatos, Putnam, van Fraassen, and others, are all considered. 'Intervening' presents the first sustained treatment of experimental science for many years and uses it to give a new direction to debates about (...) realism. Hacking illustrates how experimentation often has a life independent of theory. He argues that although the philosophical problems of scientific realism can not be resolved when put in terms of theory alone, a sound philosophy of experiment provides compelling grounds for a realistic attitude. A great many scientific examples are described in both parts of the book, which also includes lucid expositions of recent high energy physics and a remarkable chapter on the microscope in cell biology. (shrink)

Scientific realism is the view that our best scientific theories give approximately true descriptions of both observable and unobservable aspects of a mind-independent world. Debates between realists and their critics are at the very heart of the philosophy of science. Anjan Chakravartty traces the contemporary evolution of realism by examining the most promising strategies adopted by its proponents in response to the forceful challenges of antirealist sceptics, resulting in a positive proposal for scientific realism today. He examines the core principles (...) of the realist position, and sheds light on topics including the varieties of metaphysical commitment required, and the nature of the conflict between realism and its empiricist rivals. By illuminating the connections between realist interpretations of scientific knowledge and the metaphysical foundations supporting them, his book offers a compelling vision of how realism can provide an internally consistent and coherent account of scientific knowledge. (shrink)

Why does an object or phenomenon become the subject of scientific inquiry? Why do some of these objects remain provocative, while others fade from center stage? And why do objects sometimes return as the focus of research long after they were once abandoned? Addressing such questions, _Biographies of Scientific Objects_ is about how whole domains of phenomena—dreams, atoms, monsters, culture, society, mortality, centers of gravity, value, cytoplasmic particles, the self, tuberculosis—come into being and sometimes pass away as objects of scientific (...) study. With examples drawn from both the natural and social sciences, and ranging from the sixteenth to the twentieth centuries, this book explores the ways in which scientific objects are both real and historical. Whether discovered or invented, these objects of inquiry broaden and deepen in meaning—growing more "real"—as they become entangled in webs of cultural significance, material practices, and theoretical derivations. Thus their biographies will matter to anyone concerned with the formation of scientific knowledge. Contributors are Jed Z. Buchwald, Lorraine Daston, Rivka Feldhay, Jan Goldstein, Gerard Jorland, Doris Kauffman, Bruno Latour, Theodore M. Porter, Hans-Jörg Rheinberger, Marshall Sahlins, and Peter Wagner. (shrink)

Neurobiology studies mechanisms of cell signalling. A key question is how cells recognise specific signals. In this context, olfaction has become an important experimental system over the past 25 years. The olfactory system responds to an array of structurally diverse stimuli. The discovery of the olfactory receptors (ORs), recognising these stimuli, established the olfactory pathway as part of a greater group of signalling mechanisms mediated by G-protein-coupled receptors (GPCRs). GPCRs are the largest protein family in the mammalian genome and involved (...) in numerous fundamental physiological processes. The OR family exhibits two characteristics that make them an excellent model system to understand GPCRs: its size and the structural diversity of its members. Research on the OR binding site investigates what amino acid sequences determine the receptor-binding capacity. This promises a better understanding of how the basic genetic makeup of GPCRs relates to their diversification in ligand-binding capacities. (shrink)

The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental), theoretical, and philosophical (speculative) identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as 'real' as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, and was endowed with a corpuscular ontology. Lavoisier labeled it (...) as an 'imaginary' substance because it offered a unique resistance to his vision of the new chemistry based on 'metric' measurements and algebraic representations. (shrink)

This paper examines Ian Hacking's arguments in favor of entity realism. It shows that his examples from science do not support his realism. Furthermore, his proposed criterion of experimental use is neither sufficient nor necessary for conferring a privileged status on his preferred unobservables. Nonetheless his insight is genuine; it may be most profitably seen as part of a more general effort to create a space for a new form of scientific and philosophical certainty, one that does not require foundations.