Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in Migraine Without Aura
Frontiers in Human Neuroscience 14 (2020)
AbstractPrevious studies have reported abnormal amplitude of low-frequency fluctuation and regional homogeneity in patients with migraine without aura using resting-state functional magnetic resonance imaging. However, how whole brain functional connectivity pattern homogeneity and its corresponding functional connectivity changes in patients with migraine without aura is unknown. In the current study, we employed a recently developed whole brain functional connectivity homogeneity method to identify the voxel-wise changes of functional connectivity patterns in 21 patients with migraine without aura and 21 gender and age matched healthy controls. Moreover, resting-state functional connectivity analysis was used to reveal the changes of corresponding functional connectivities. FcHo analyses identified significantly decreased FcHo values in the posterior cingulate cortex, thalamus, and left anterior insula in patients with migraine without aura compared to healthy controls. Functional connectivity analyses further found decreased functional connectivities between PCC and medial prefrontal cortex, between AI and anterior cingulate cortex, and between THA and left precentral gyrus. The functional connectivities between THA and PCG were negatively correlated with pain intensity. Our findings indicated that whole brain FcHo and connectivity abnormalities of these regions may be associated with functional impairments in pain processing in patients with migraine without aura.
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References found in this work
Large-Scale Brain Networks and Psychopathology: A Unifying Triple Network Model.Vinod Menon - 2011 - Trends in Cognitive Sciences 15 (10):483-506.
Emotional Processing in Anterior Cingulate and Medial Prefrontal Cortex.Amit Etkin, Tobias Egner & Raffael Kalisch - 2011 - Trends in Cognitive Sciences 15 (2):85-93.
Whole Brain Functional Connectivity Pattern Homogeneity Mapping.Lijie Wang, Jinping Xu, Chao Wang & Jiaojian Wang - 2018 - Frontiers in Human Neuroscience 12.
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