CRISPR Cautions: Biosecurity Implications of Gene Editing

Perspectives in Biology and Medicine 63 (1):73-92 (2020)
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Abstract

CRISPR, a recently developed gene-editing tool, has become synonymous with rapid biological advancement. While gene editing had been performed in life sciences research for decades, genetic engineering with CRISPR is much more straightforward, faster, and less expensive—and thus, the technology has been rapidly democratized. CRISPR was built on a natural mechanism, the method by which bacteria resist infections from viruses called bacteriophage. Once infected, bacteria may recognize specific genetic sequences of the invading bacteriophage virus and chop its genetic material into pieces. This bacterial immune response, discovered through basic research, has been exploited by scientists to develop a gene-editing tool...

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