Abstract
Nicholas of Cusa, represents an important crossroads in 15th century philosophy. It can be said that the philosophy tradition to which Cusa was articulated had an effect on the differentiation of the conception of the world of science and philosophy under the domination of Scholastic thought in the Middle Ages. Cusa made a clear distinction between the finite and the infinite, with the theological understanding of being, which he put forward on the basis of Plato's philosophy. In his theology, which he shaped by centered on the idea of the unity of God, he dealt with the God-universe relationship, which he developed in this unity perspective, with a dialectical approach, in the understanding of equality and non-equality. Since Cusa owes God and the continuation of his existence to God, he saw the world in one aspect, argued that they were unknowable in nature, and affirmed the ignorance in this field by making it dependent on a divine understanding. On the other hand, with the perspective that does not ignore the possibilities of humanist, skeptical and scientific knowledge, which he developed in accordance with the spirit of the period in which he lived, he almost made the news of modern science and philosophy with the mathematical method he thought would obtain the knowledge of the world. This study was carried out to examine the understanding of existence in the philosophy of Nicholas of Cusa within the framework of God-universe relationship.