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| Abstract |
Cancer is not one, but many diseases, and each is a product of a variety of causes acting (and interacting) at distinct temporal and spatial scales, or “levels” in the biological hierarchy. In part because of this diversity of cancer types and causes, there has been a diversity of models, hypotheses, and explanations of carcinogenesis. However, there is one model of carcinogenesis that seems to have survived the diversification of cancer types: the multi-stage model of carcinogenesis. This paper examines the history of the multistage theory, and uses the theory as a case study in the limits and goals of unification as a theoretical virtue, comparing and contrasting it with “integrative” research.
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| Keywords | Cancer Integration Unification |
| Categories | (categorize this paper) |
| DOI | 10.1016/j.shpsc.2013.03.019 |
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References found in this work BETA
Explaining the Brain: Mechanisms and the Mosaic Unity of Neuroscience.Carl F. Craver - 2007 - Oxford University Press, Clarendon Press.
Simulation and Similarity: Using Models to Understand the World.Michael Weisberg - 2013 - Oxford University Press.
Progress and its Problems: Toward a Theory of Scientific Growth.Larry Laudan - 1977 - University of California Press.
View all 55 references / Add more references
Citations of this work BETA
Systems Biology and the Integration of Mechanistic Explanation and Mathematical Explanation.Ingo Brigandt - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):477-492.
What Makes Interdisciplinarity Difficult? Some Consequences of Domain Specificity in Interdisciplinary Practice.Miles MacLeod - 2018 - Synthese 195 (2):697-720.
Integrating Data to Acquire New Knowledge: Three Modes of Integration in Plant Science.Sabina Leonelli - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):503-514.
On the Nature of Cross-Disciplinary Integration: A Philosophical Framework.Michael O'Rourke, Stephen Crowley & Chad Gonnerman - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 56:62-70.
Integration in Biology: Philosophical Perspectives on the Dynamics of Interdisciplinarity.Ingo Brigandt - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):461-465.
View all 20 citations / Add more citations
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