Regulating trust in pediatric clinical trials

Medicine, Health Care and Philosophy 11 (4):439-444 (2008)
  Copy   BIBTEX


The participation of minors in clinical trials is essential to provide safe and effective medical care to children. Because few drugs have been tested in children, pediatricians are forced to prescribe medications off-label with uncertain efficacy and safety. In this article, we analyze how the enrollment of minors in clinical trials is negotiated within relationships of mutual trust between clinicians, minors, and their parents. After a brief description of the problems associated with involving minors in clinical research, we consider how existing “relationships of trust” can be used as a place where the concerns of research subjects can be more fully discussed and addressed. Building on the tacit recognition of trust found in The European Clinical Trials Directive we make policy recommendations that allow for clearer, more ethically informed guidelines for enrolling minors in clinical research



    Upload a copy of this work     Papers currently archived: 93,745

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Ethics status of clinical research and trials in developing countries.Yuanyuan Liu - 2015 - Eubios Journal of Asian and International Bioethics 25 (4):124-127.
Institutional mistrust in the organization of pharmaceutical clinical trials.Jill A. Fisher - 2008 - Medicine, Health Care and Philosophy 11 (4):403-413.


Added to PP

30 (#132,620)

6 months
12 (#1,086,452)

Historical graph of downloads
How can I increase my downloads?