Assessment of Bis-macrocyclic Compounds as Calcium-sensitive MR Contrast Agents

Abstract

The ability of non-invasively observing changes in the Ca2+ concentrations is important in the understanding of a great variety of neuronal processes. Several compounds were designed (Fig.1) to take advantage of the different binding abilities of carboxylates and phosphonates to gadolinium. Furthermore the different affinities of the two functional groups to Ca2+ permit to obtain free coordination sites at gadolinium. The generation of these coordination sites, which are mandatory for water relaxivity, depends on the structure of the complexes and the Ca2+ concentration. Gadolinium complexes 1 and 2 were synthesized and relaxivity studies were performed.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 90,616

External links

  • This entry has no external links. Add one.
Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

  • Only published works are available at libraries.

Similar books and articles

The need for growth promoting compounds in poultry meat production.S. Leeson - 1991 - Journal of Agricultural and Environmental Ethics 4 (1):89-99.
Elements, Compounds, and Other Chemical Kinds.Robin Findlay Hendry - 2006 - Philosophy of Science 73 (5):864-875.
Making sense of relative truth.John MacFarlane - 2005 - Proceedings of the Aristotelian Society 105 (3):321–339.

Analytics

Added to PP
2010-12-22

Downloads
20 (#656,247)

6 months
1 (#1,040,386)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references