Journal of Medicine and Philosophy 42 (3):328-341 (2017)

Abstract
The possibility of performing germline modifications on currently living individuals targets future generations’ health and well-being by reducing the diversity of the human gene pool. This can have two negative repercussions: reduction of heterozygosity, the latter being associated with a health or performance advantage; uniformization of the genes involved in reproductive recombination, which may lead to the health risks involved in asexual reproduction. I argue that germline interventions aimed at modifying the genomes of future people cannot be ethically justifiable if there is no possibility of controlling the intervention either by reversing or altering it, whenever need demands it. This argument is challenged on six different grounds: safety, population versus individual focus, spontaneous mutations, exceptionalism, the intentional pursuit of genetic diversity through germline interventions, and harm reduction potential.
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DOI 10.1093/jmp/jhx003
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References found in this work BETA

The Wisdom of Nature: An Evolutionary Heuristic for Human Enhancement.Nick Bostrom & Anders Sandberg - 2009 - In Julian Savulescu & Nick Bostrom (eds.), Human Enhancement. Oxford University Press. pp. 375--416.
Natural History of Ashkenazi Intelligence.Gregory Cochran, Jason Hardy & Henry Harpending - 2006 - Journal of Biosocial Science 38 (5):659-693.

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Bioethics and Transhumanism.Porter Allen - 2017 - Journal of Medicine and Philosophy 42 (3):237-260.
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