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Sequence Matters: Genomic Research and the Gene Concept
Philosophy of Science 78 (5):752-762 (2011)
Abstract
Analysis of two key ways of characterizing genes—as causes of phenotypic effects and as genomic DNA sequences—has yielded widespread pessimism that they can be united in a coherent gene concept. This raises important questions about the epistemology of genomic research: If analysis of a genome sequence cannot yield information about genes defined both in terms of their products and their DNA sequence, then what could we learn from it? I investigate basic tools of genomic analysis, argue that they do not reflect the application of either gene concept, and clarify how we learn from genomic research.Author's Profile
DOI
10.1086/662565
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Citations of this work
Why genes are like lemons.F. Boem, E. Ratti, M. Andreoletti & G. Boniolo - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 57 (June):88-95.
The emergence of the postgenomic gene.Francesca Bellazzi - 2022 - European Journal for Philosophy of Science 12 (1):1-21.
References found in this work
Tracking the shift to 'postgenomics'.Karola Stotz, Adam Bostanci & Paul E. Griffiths - 2006 - Community Genetics 9 (3).
Redundancy, Plasticity, and Detachment: The Implications of Comparative Genomics for Evolutionary Thinking.Lenny Moss - 2006 - Philosophy of Science 73 (5):930-946.
What does it mean to be 75% pumpkin? The units of comparative genomics.Monika Piotrowska - 2009 - Philosophy of Science 76 (5):838-850.
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