Topoisomerase II may be linked to the reduction of chromosome number in meiosis

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Bioessays 25 (4):309-312 (2003)
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Abstract

A reduction of chromosome number in meiosis is essential for genome transmission in diploid organisms. Reduction depends on a change in kinetochore configuration.1 A recent study2 connects changes in kinetochores with other changes in chromosome structure and raises the intriguing possibility that topoisomerase II, the DNA untangling enzyme, is involved. BioEssays 25:309–312, 2003. © 2003 Wiley Periodicals, Inc.

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10.1002/bies.10265

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