Structure and evolution of insulins: Implications for receptor binding

Bioessays 14 (5):325-331 (1992)
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Abstract

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common ‘insulin fold’ is probably adopted by all family members. Although the specificities of receptor binding are different, there is possibility of co‐evolution of polypeptides and their receptors.

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