Apical amplification—a cellular mechanism of conscious perception?

Neuroscience of Consciousness 7 (2):1-17 (2021)
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Abstract

We present a theoretical view of the cellular foundations for network-level processes involved in producing our conscious experience. Inputs to apical synapses in layer 1 of a large subset of neocortical cells are summed at an integration zone near the top of their apical trunk. These inputs come from diverse sources and provide a context within which the transmission of information abstracted from sensory input to their basal and perisomatic synapses can be amplified when relevant. We argue that apical amplification enables conscious perceptual experience and makes it more flexible, and thus more adaptive, by being sensitive to context. Apical amplification provides a possible mechanism for recurrent processing theory that avoids strong loops. It makes the broadcasting hypothesized by global neuronal workspace theories feasible while preserving the distinct contributions of the individual cells receiving the broadcast. It also provides mechanisms that contribute to the holistic aspects of integrated information theory. As apical amplification is highly dependent on cholinergic, aminergic, and other neuromodulators, it relates the specific contents of conscious experience to global mental states and to fluctuations in arousal when awake. We conclude that apical dendrites provide a cellular mechanism for the context-sensitive selective amplification that is a cardinal prerequisite of conscious perception.

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Author Profiles

Tomas Marvan
Czech Academy of Sciences
William Phillips
University of California, Berkeley

Citations of this work

Consciousness and content in perception.Bill Brewer - 2017 - Philosophical Perspectives 31 (1):41-54.

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References found in this work

Levels of processing during non-conscious perception: A critical review of visual masking.Sid Kouider & Stanislas Dehaene - 2007 - Philosophical Transactions of the Royal Society of London, B 362 (1481):857-875.
Psychophysical magic: rendering the visible 'invisible'.Chai-Youn Kim & Randolph Blake - 2005 - Trends in Cognitive Sciences 9 (8):381-388.
Toward a theory of visual consciousness.Semir Zeki & Andreas Bartels - 1999 - Consciousness and Cognition 8 (2):225-59.
In search of common foundations for cortical computation.William A. Phillips & Wolf Singer - 1997 - Behavioral and Brain Sciences 20 (4):657-683.

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