The evolution of dynamin to regulate clathrin‐mediated endocytosis

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Bioessays 34 (8):643-647 (2012)
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Abstract

Graphical AbstractWhereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

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10.1002/bies.201200033

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