With the development of economic globalization, more and more clinical research and trials shift from developed countries to developing countries. The globalization of clinical trials also brings some ethical and scientific concerns. This paper discussed some ethical problems of clinical trials in the developing countries including 1) "golden rice" event in China; 2) Informed consent in clinical trials in developing countries; 3) Ethical consciousness in clinical research and trials in developing countries. The essay suggests that the level of medical ethics in developing countries is lower than that in developed countries. How can we improve the ethical consciousness of clinical researchers and subjects and how can we protect patient rights are important problems faced by developing countries.