Basic Formal Ontology for bioinformatics

IFOMIS Reports (2005)
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Two senses of ‘ontology’ can be distinguished in the current literature. First is the sense favored by information scientists, who view ontologies as software implementations designed to capture in some formal way the consensus conceptualization shared by those working on information systems or databases in a given domain. [Gruber 1993] Second is the sense favored by philosophers, who regard ontologies as theories of different types of entities (objects, processes, relations, functions) [Smith 2003]. Where information systems ontologists seek to maximize reasoning efficiency even at the price of simplifications on the side of representation, philosophical ontologists argue that representational adequacy can bring benefits for the stability and resistance to error of an ontological framework and also for its extendibility in the future. In bioinformatics, however, a third sense of ‘ontology’ has established itself, above all as a result of the successes of the Gene Ontology (hereafter: GO), which is a tool for the representation and processing of information about gene products and their biological functions [Gene Ontology Consortium 2000]. We show how Basic Formal Ontology (BFO) has established itself as an overarching ontology drawing on all three of the strands distinguished above, and describe applications of BFO especially in the treatment of biological granularity.



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Author Profiles

Barry Smith
University at Buffalo
Thomas Bittner
State University of New York, Buffalo

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References found in this work

A Theory of Granular Partitions.Thomas Bittner & Barry Smith - 2003 - In Matt Duckham, Michael F. Goodchild & Michael Worboys (eds.), Foundations of Geographic Information Science. London: Taylor & Francis. pp. 117-151.
A unified theory of truth and reference.Barry Smith & Berit Brogaard - 2000 - Logique Et Analyse 43 (169-170):49–93.
The ontology of the Gene Ontology.Barry Smith, Jennifer Williams & Steffen Schulze-Kremer - 2003 - In Smith Barry, Williams Jennifer & Schulze-Kremer Steffen (eds.), AMIA 2003 Symposium Proceedings. AMIA. pp. 609-613.

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