Anubhav Jain, Kian Abedinpour, Ozgur Polat, Mine Melodi Çalışkan, Afsaneh Asaei, Franz M. J. Pfister, Urban M. Fietzek & Milos Cernak
Frontiers in Human Neuroscience 15 (2021)
AbstractHumans' voice offers the widest variety of motor phenomena of any human activity. However, its clinical evaluation in people with movement disorders such as Parkinson's disease lags behind current knowledge on advanced analytical automatic speech processing methodology. Here, we use deep learning-based speech processing to differentially analyze voice recordings in 14 people with PD before and after dopaminergic medication using personalized Convolutional Recurrent Neural Networks and Phone Attribute Codebooks. p-CRNN yields an accuracy of 82.35% in the binary classification of ON and OFF motor states at a sensitivity/specificity of 0.86/0.78. The PAC-based approach's accuracy was slightly lower with 73.08% at a sensitivity/specificity of 0.69/0.77, but this method offers easier interpretation and understanding of the computational biomarkers. Both p-CRNN and PAC provide a differentiated view and novel insights into the distinctive components of the speech of persons with PD. Both methods detect voice qualities that are amenable to dopaminergic treatment, including active phonetic and prosodic features. Our findings may pave the way for quantitative measurements of speech in persons with PD.
Similar books and articles
Ten Years of Research on Automatic Voice and Speech Analysis of People With Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review Article.Israel Martínez-Nicolás, Thide E. Llorente, Francisco Martínez-Sánchez & Juan José G. Meilán - 2021 - Frontiers in Psychology 12.
Early Detection of Parkinson’s Disease by Using SPECT Imaging and Biomarkers.Bhanu Prasad, T. N. Nagabhushan & Gunjan Pahuja - 2019 - Journal of Intelligent Systems 29 (1):1329-1344.
Neural Transplants for Parkinson’s Disease: What Are the Issues?Roger Barker - 2006 - Poiesis and Praxis 4 (2):129-143.
When My Voice is Not My Voice: Speaking Through a Speech Generating Device.Kathy Howery - 2018 - Phenomenology and Practice 12 (1):4-17.
Bringing back the voice: on the auditory objects of speech perception.Anna Drożdżowicz - 2020 - Synthese (x):1-27.
The NGF Superfamily of Neurotrophins: Potential Treatment for Alzheimer's and Parkinson's Disease.Elliott J. Mufson & Teresa Sobreviela - 1995 - Behavioral and Brain Sciences 18 (1):63-65.
Individual Magnetoencephalography Response Profiles to Short-Duration L-Dopa in Parkinson’s Disease.Edgar Peña, Tareq M. Mohammad, Fedaa Almohammed, Tahani AlOtaibi, Shahpar Nahrir, Sheraz Khan, Vahe Poghosyan, Matthew D. Johnson & Jawad A. Bajwa - 2021 - Frontiers in Human Neuroscience 15.
What Catatonia Can Tell Us About “Top-Down Modulation”: A Neuropsychiatric Hypothesis.Georg Northoff - 2002 - Behavioral and Brain Sciences 25 (5):555-577.
Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease.Xue Q. Yang, Brian Lauzon, Ken N. Seergobin & Penny A. MacDonald - 2018 - Frontiers in Human Neuroscience 11.
ANN for Parkinson’s Disease Prediction.Salah Sadek, Abdul Mohammed, Abdul Karim Abunbehan, Majed Abdul Ghattas & Mohamed Badawi - 2020 - International Journal of Academic Health and Medical Research (IJAHMR) 3 (1):1-7.
How Religiosity Affects Parkinson’s Disease Symptoms.Daniel Docu-Axelerad, Silviu Docu Axelerad & Alina Zorina Stroe - 2019 - Dialogo 6 (1):203-211.
Dopaminergic Modulation of Positive Expectations for Goal-Directed Action: Evidence From Parkinson’s Disease.Noham Wolpe, Cristina Nombela & James B. Rowe - 2015 - Frontiers in Psychology 6.
Cognitive Impairment and Dementia in Parkinson's Disease.Murat Emre (ed.) - 2010 - Oxford University Press UK.
Parkinson’s Disease Prediction Using Artificial Neural Network.Ramzi M. Sadek, Salah A. Mohammed, Abdul Rahman K. Abunbehan, Abdul Karim H. Abdul Ghattas, Majed R. Badawi, Mohamed N. Mortaja, Bassem S. Abu-Nasser & Samy S. Abu-Naser - 2019 - International Journal of Academic Health and Medical Research (IJAHMR) 3 (1):1-8.
Added to PP
Historical graph of downloads