In this brief paper, I want to begin to explore the possibility that bi-trans dialogue can challenge those forms of oppression that are grounded in sex, gender, and sexuality. I am particularly interested in pursuing the possibility that bi-trans dialogue might result in additional critiques of the sex-gender-sexuality triad. Despite multiple challenges, and myriad historical transmogri-fications (including, it must be noted, the very late addition of gender), that triad maintains its foundationality and posits deep causal links among its three parts. The effect of this causal chain is to render untenable or incomprehensi-ble the lives of all sorts of actual, living persons—lives that are anything but incomprehensible to those living them, but that are made to be so on a system in which there is still a strong tendency to hold that sex causes gender and sexuality. The resilience of this presumed causal connection contributes to ensuring the continued dominance of a two-sex, two-gender, two-sexuality system.