Ethical Arguments Concerning Human-Animal Chimera Research: A Systematic Review

BMC Medical Ethics 21:1-14 (2020)
  Copy   BIBTEX


The burgeoning field of biomedical research involving the mixture of human and animal materials has attracted significant ethical controversy. Due to the many dimensions of potential ethical conflict involved in this type of research, and the wide variety of research projects under discussion, it is difficult to obtain an overview of the ethical debate. This paper attempts to remedy this by providing a systematic review of ethical reasons in academic publications on human-animal chimera research. We conducted a systematic review of the ethical literature concerning human-animal chimeras based on the research question: “What ethical reasons have been given for or against conducting human-animal chimera research, and how have these reasons been treated in the ongoing debate?” Our search extends until the end of the year 2017, including MEDLINE, Embase, PhilPapers and EthxWeb databases, restricted to peer-reviewed journal publications in English. Papers containing ethical reasons were analyzed, and the reasons were coded according to whether they were endorsed, mentioned or rejected. Four hundred and thirty-one articles were retrieved by our search, and 88 were ultimately included and analyzed. Within these articles, we found 464 passages containing reasons for and against conducting human-animal chimera research. We classified these reasons into five categories and, within these, identified 12 broad and 31 narrow reason types.15% of the retrieved passages contained reasons in favor of conducting chimera research, while 85% of the passages contained reasons against it. The reasons against conducting chimera research fell into four further categories: reasons concerning the creation of a chimera, its treatment, reasons referring to metaphysical or social issues resulting from its existence and to potential downstream effects of chimera research. A significant proportion of identified passages fell under Category C. We hope that our results, in revealing the conceptual and argumentative structure of the debate and highlighting some its most notable tendencies and prominent positions, will facilitate continued discussion and provide a basis for the development of relevant policy and legislation.



    Upload a copy of this work     Papers currently archived: 91,102

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Chimeras and human dignity.Inmaculada de Melo-Martín - 2008 - Kennedy Institute of Ethics Journal 18 (4):pp. 331-346.
Embryo Research: The Ethical Geography of the Debate.G. Khushf - 1997 - Journal of Medicine and Philosophy 22 (5):495-519.


Added to PP

35 (#408,502)

6 months
6 (#252,172)

Historical graph of downloads
How can I increase my downloads?

Author Profiles

Lucie White
Utrecht University
Dietmar Hübner
Universität Hannover

References found in this work

Crossing species boundaries.Jason Scott Robert & Françoise Baylis - 2003 - American Journal of Bioethics 3 (3):1 – 13.
At the edge of humanity: Human stem cells, chimeras, and moral status.Robert Streiffer - 2005 - Kennedy Institute of Ethics Journal 15 (4):347-370.
How to write a systematic review of reasons.Daniel Strech & Neema Sofaer - 2012 - Journal of Medical Ethics 38 (2):121-126.

View all 85 references / Add more references