Model for DNA and Protein Interactions and the Function of the Operator

Nature 212:1480-1481 (1966)
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Abstract

The short paper introduces the concept of possible branches of double-stranded DNA (later sometimes called palindromes): Certain sequences of nucleotides may be followed, after a short unpaired stretch, by a complementary sequence in reversed order, such that each DNA strand can fold back on itself, and the DNA assumes a cruciform or tree-like structure. This is postulated to interact with regulatory proteins.

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Alfred Gierer
Max-Planck-Institute of Developmental Biology, Tuebingen, Germany

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