Beyond the dichotomy in vivo - in vitro: In silico

Abstract

From the beginnings of the biochemistry as discipline, the dichotomy between in vivo- in vitro conditions has been in the center of their methodological discussions. With the growing influence of computer simulations - sometimes called "in silico" conditions-, a new methodological problem is added to biochemistry. However, "simulation" could be seen as a core concept that is in fact used in the in vivo - in vitro dichotomy. In this sense, in silico dimension could be considered as a natural extension of the classical dichotomy. From the way in which simulation is used on in vivo-in vitro dichotomy, we also suggest that the general idea of simulation proposed by Hartmann have to be redefined. The intuitive idea of simulation resting on “imitation” relationship, as a “process that imitates another process” (Hartmann 1996), has to be complemented by others methodological concepts like “isolation” or “disruption”.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 76,419

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

  • Only published works are available at libraries.

Similar books and articles

New times for biology: Nerve cultures and the advent of cellular life in vitro.H. Landecker - 2002 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (4):667-694.

Analytics

Added to PP
2009-01-28

Downloads
44 (#267,872)

6 months
1 (#452,962)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Citations of this work

No citations found.

Add more citations