Prognostic Value of Resting-State EEG Structure in Disentangling Vegetative and Minimally Conscious States: A Preliminary Study

Neurorehabilitation and Neural Repair 27 (4):345-354 (2013)
  Copy   BIBTEX


Background: Patients in a vegetative state pose problems in diagnosis, prognosis and treatment. Currently, no prognostic markers predict the chance of recovery, which has serious consequences, especially in end-of-life decision-making. Objective: We aimed to assess an objective measurement of prognosis using advanced electroencephalography (EEG). Methods: EEG data (19 channels) were collected in 14 patients who were diagnosed to be persistently vegetative based on repeated clinical evaluations at 3 months following brain damage. EEG structure parameters (amplitude, duration and variability within quasi-stationary segments, as well as the spatial synchrony between such segments and the strength of this synchrony) were used to predict recovery of consciousness 3 months later. Results: The number and strength of cortical functional connections between EEG segments were higher in patients who recovered consciousness (P < .05 – P < .001) compared with those who did not recover. Linear regression analysis confirms that EEG structure parameters are capable of predicting (P = .0025) recovery of consciousness 6 months post-injury, whereas the same analysis failed to significantly predict patient outcome based on aspects of their clinical history alone (P = .629) or conventional EEG spectrum power (P = .473). Conclusions: The result of this preliminary study demonstrates that structural strategy of EEG analysis is better suited for providing prognosis of consciousness recovery than existing methods of clinical assessment and of conventional EEG. Our results may be a starting point for developing reliable prognosticators in patients who are in vegetative state, with the potential to improve their day-to-day management, quality of life, and access to early interventions.



    Upload a copy of this work     Papers currently archived: 84,179

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Brain damage and the moral significance of consciousness.Guy Kahane & Julian Savulescu - 2009 - Journal of Medicine and Philosophy 34 (1):6-26.
The Vegetative State and the Science of Consciousness.Nicholas Shea & Tim Bayne - 2010 - British Journal for the Philosophy of Science 61 (3):459-484.


Added to PP

114 (#126,526)

6 months
3 (#247,768)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Andrew And Alexander Fingelkurts
BM-Science - Brain and Mind Technologies Research Centre

References found in this work

No references found.

Add more references