Images of cell trees, cell lines, and cell fates: the legacy of Ernst Haeckel and August Weismann in stem cell research

History and Philosophy of the Life Sciences 36 (2):157-186 (2014)
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Abstract

Stem cells did not become a proper research object until the 1960 s. Yet the term and the basic mind-set—namely the conception of single undifferentiated cells, be they embryonic or adult, as the basic units responsible for a directed process of development, differentiation and increasing specialisation—were already in place at the end of the nineteenth century and then transmitted on a non-linear path in the form of tropes and diagrams. Ernst Haeckel and August Weismann played a special role in this story. The first coined the term Stammzelle (stem cell), the second was the author of the first cellular stem-tree diagram. Even today, I shall argue, the understanding of stem cells, especially the popular perception, is to a large extent a Haeckelian–Weismannian one. After having demonstrated this, by analysing the terminology, in this essay I will focus on the use of cytogenetic tree diagrams between 1892 and 1925 and on the tacit understanding of stem cells that they transmit.

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what is a lineage?Celso Neto - 2019 - Philosophy of Science 86 (5):1099-1110.

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References found in this work

August Weismann on Germ-Plasm Variation.Rasmus Grønfeldt Winther - 2001 - Journal of the History of Biology 34 (3):517-555.
The Germ Plasm: a Theory of Heredity.A. Weismann - 1893 - Philosophical Review 2:373.
When integration fails: Prokaryote phylogeny and the tree of life.Maureen A. O’Malley - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4a):551-562.

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