Bioessays 38 (7):605-612 (2016)

Transcription factors (TFs) have to find their binding sites, which are distributed throughout the genome. Facilitated diffusion is currently the most widely accepted model for this search process. Based on this model the TF alternates between one‐dimensional sliding along the DNA, and three‐dimensional bulk diffusion. In this view, the non‐specific associations between the proteins and the DNA play a major role in the search dynamics. However, little is known about how the DNA properties around the motif contribute to the search. Accumulating evidence showing that TF binding sites are embedded within a unique environment, specific to each TF, leads to the hypothesis that the search process is facilitated by favorable DNA features that help to improve the search efficiency. Here, we review the field and present the hypothesis that TF‐DNA recognition is dictated not only by the motif, but is also influenced by the environment in which the motif resides.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1002/bies.201600005
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 71,379
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

The Needle in the Haystack.James C. Bearden - 1977 - Perspectives in Biology and Medicine 20 (3):355-359.
The CSR Needle in the CR Haystack.William C. Frederick - 2013 - Business and Professional Ethics Journal 32 (1-2):131-136.


Added to PP index

Total views
5 ( #1,207,854 of 2,519,679 )

Recent downloads (6 months)
1 ( #406,314 of 2,519,679 )

How can I increase my downloads?


My notes