Reasoning Strategies in Molecular Biology: Abstractions, Scans and Anomalies

PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:179 - 191 (1994)
  Copy   BIBTEX

Abstract

Molecular biologists use different kinds of reasoning strategies for different tasks, such as hypothesis formation, experimental design, and anomaly resolution. More specifically, the reasoning strategies discussed in this paper may be characterized as (1) abstraction-instantiation, in which an abstract skeletal model is instantiated to produce an experimental system; (2) the systematic scan, in which alternative hypotheses are systematically generated; and (3) modular anomaly resolution, in which components of a model are stated explicitly and methodically changed to generate alternative changes to resolve an anomaly. This work grew out of close observation over a period of six months of an actively functioning molecular genetics laboratory.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 76,199

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Anomaly-driven theory redesign: computational philosophy of science experiments.Lindley Darden - 1998 - In T. W. Bynum & J. Moor (eds.), The Digital Phoenix. Cambridge: Blackwell. pp. 62--78.
The Adaptive Radiation of Biological Explanation.Niall Shanks - 2001 - Idealistic Studies 31 (2/3):155-168.
Procedural knowledge in molecular biology.Baljinder Sahdra & Paul Thagard - 2003 - Philosophical Psychology 16 (4):477 – 498.
Mechanism schemas and the relationship between biological theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
Strategies of Model Building in Population Genetics.Anya Plutynski - 2006 - Philosophy of Science 73 (5):755-764.
Strategies for Anomaly Resolution.Lindley Darden - 1992 - In R. Giere & H. Feigl (eds.), Cognitive Models of Science. University of Minnesota Press.
Approximations, Idealizations and 'Experiments' at the Physics-Biology Interface.Darrell Patrick Rowbottom - 2008 - Studies in History and Philosophy of Biological and Biomedical Sciences 42 (2):145-154.
Strategies of abstraction.Richard Levins - 2006 - Biology and Philosophy 21 (5):741-755.
Naturalists, Molecular Biologists, and the Challenges of Molecular Evolution.Joel B. Hagen - 1999 - Journal of the History of Biology 32 (2):321 - 341.
National politics and international trends: EMBO and the making of molecular biology in Spain (1960-1975).J. M. - 2002 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (3):473-487.
Microbes modeling ontogeny.Alan C. Love & Michael Travisano - 2013 - Biology and Philosophy 28 (2):161-188.

Analytics

Added to PP
2011-05-29

Downloads
24 (#482,932)

6 months
2 (#297,737)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Lindley Darden
University of Maryland, College Park

Citations of this work

Strategies in the interfield discovery of the mechanism of protein synthesis.Lindley Darden & Carl Craver - 2002 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 33 (1):1-28.

Add more citations

References found in this work

No references found.

Add more references