Antifragility and Tinkering in Biology (and in Business) Flexibility Provides an Efficient Epigenetic Way to Manage Risk

Genes 2 (4):998-1016 (2011)
  Copy   BIBTEX

Abstract

The notion of antifragility, an attribute of systems that makes them thrive under variable conditions, has recently been proposed by Nassim Taleb in a business context. This idea requires the ability of such systems to ‘tinker’, i.e., to creatively respond to changes in their environment. A fairly obvious example of this is natural selection-driven evolution. In this ubiquitous process, an original entity, challenged by an ever-changing environment, creates variants that evolve into novel entities. Analyzing functions that are essential during stationary-state life yield examples of entities that may be antifragile. One such example is proteins with flexible regions that can undergo functional alteration of their side residues or backbone and thus implement the tinkering that leads to antifragility. This in-built property of the cell chassis must be taken into account when considering construction of cell factories driven by engineering principles.

Links

PhilArchive

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

A curiously ubiquitous articulatory movement.Björn Lindblom - 1998 - Behavioral and Brain Sciences 21 (4):521-522.
Strategic reputation risk management.Judy Larkin - 2003 - New York: Palgrave-Macmillan.
Bridges between development and evolution.Eva Jablonka & Marion J. Lamb - 1998 - Biology and Philosophy 13 (1):119-124.
Cognitive and psychiatric science beyond determinism.Dan J. Stein - 1999 - Behavioral and Brain Sciences 22 (5):906-907.

Analytics

Added to PP
2012-11-24

Downloads
385 (#53,990)

6 months
66 (#76,014)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Antoine Danchin
University of Hong Kong

References found in this work

No references found.

Add more references