Combinations of Histone Modifications for Pattern Genes

&
Acta Biotheoretica 64 (2):121-132 (2016)
  Copy   BIBTEX

Abstract

Histone post-translational modifications play important roles in transcriptional regulation. It is known that multiple histone modifications can act in a combinatorial manner. In this study, we investigated the effects of multiple histone modifications on expression levels of five gene categories in coding regions. The combinatorial patterns of modifications for the five gene categories were also studied in the regions. Our results indicated that the differences in the expression levels between any two gene categories were significant. There were some corresponding differences in multiple histone modification levels among the five gene categories. Multiple histone modifications jointly impacted expression levels of every gene category. Four mutual combinations of histone modifications were found and analyzed.

Categories

Keywords

Reprint years

DOI

10.1007/s10441-016-9276-1

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 91,252

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

My notes

Similar books and articles

All about histone genes. Histone genes: Structure, organization, and regulation. Edited by G. S. S TEIN, J. L. S TEIN and W. F. M ARZLUFF. John Wiley and Sons, New York, Chichester, 1984. Pp. 483. £78.70, $105.75. [REVIEW]Lynna M. Hereford - 1985 - Bioessays 2 (1):43-43.
Is the “Histone Code” an Organic Code?Stefan Kühn & Jan-Hendrik S. Hofmeyr - 2014 - Biosemiotics 7 (2):203-222.
Histone modifications proposed to regulate sexual differentiation of brain and behavior.Khatuna Gagnidze, Zachary M. Weil & Donald W. Pfaff - 2010 - Bioessays 32 (11):932-939.
The heat shock genes: A family of highly conserved genes with a superbly complex expression pattern.Richard Voellmy - 1984 - Bioessays 1 (5):213-217.
The tubulin and histone genes of Physarum polycephalum: Models for cell cycle‐regulated gene expression.Thomas G. Laffler & John J. Carrino - 1986 - Bioessays 5 (2):62-65.
Epigenetic cancer therapy: Proof of concept and remaining challenges.Cora Mund & Frank Lyko - 2010 - Bioessays 32 (11):949-957.
Histone crotonylation specifically marks the haploid male germ cell gene expression program.Emilie Montellier, Sophie Rousseaux, Yingming Zhao & Saadi Khochbin - 2012 - Bioessays 34 (3):187-193.
Genes and Genomes: Genes, Genes and More Genes in the Human Major Histocompatibility Complex.Caroline M. Milner & R. Duncan Campbell - 1992 - Bioessays 14 (8):565-571.
What is a Gene? From molecules to metaphysics.Holmes Rolston - 2006 - Theoretical Medicine and Bioethics 27 (6):471-497.
Transfer of a pattern versus component discrimination following training in a probabilistic situation.Marcia D. Johns - 1965 - Journal of Experimental Psychology 70 (5):506.
Replication stress, a source of epigenetic aberrations in cancer?Zuzana Jasencakova & Anja Groth - 2010 - Bioessays 32 (10):847-855.
Algorithms and complexity in biological pattern formation problems.D. Grigoriev & S. Vakulenko - 2006 - Annals of Pure and Applied Logic 141 (3):412-428.
Tumor suppressor genes, tissue pattern control, and tumorigenesis.Ian Buckley - 1991 - Perspectives in Biology and Medicine 36 (1):24-38.
Do epigenetic pathways initiate late onset Alzheimer disease : towards a new paradigm.S. W. Bihaqi, A. Schumacher, B. Maloney, D. K. Lahiri & N. H. Zawia - 2012 - Curr Alzheimer Res 9:574-88.
Anterior‐posterior pattern formation: An evolutionary perspective on genes specifying terminal domains.Teresa R. Strecker & Judith A. Lengyel - 1988 - Bioessays 9 (1):1-7.

Analytics

Added to PP
2016-06-30

Downloads
23 (#648,182)

6 months
4 (#724,033)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references