Placebo Surgery for Parkinson's Disease: Do the Benefits Outweigh the Risks?

Journal of Law, Medicine and Ethics 30 (1):58-68 (2002)
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Abstract

In April 1999, Dr. Curt Freed of the University of Colorado in Denver and Dr. Stanley Fahn of Columbia Presbyterian Center in New York presented the results of a four-year, $5.7 million government-financed study using tissue from aborted fetuses to treat Parkinson’s disease at a conference of the American Academy of Neurology. The results of the first government-financed, placebo-controlled clinical study using fetal tissue showed that the symptoms of some Parkinson’s patients had been relieved. This research study involved forty subjects, nineteen women and twenty-one men; all suffered from Parkinson’s disease for an average of 13.5 years. In the study, each subject underwent neurosurgery: “four tiny burr holes, drilled through the wrinkle lines above the eyebrows into the skull, to clear a pathway to the brain. But only half received injections of fetal cells into the putamen, the region of the brain that controls movement; the other half received nothing. One year later, three members of the placebo group said their symptoms had improved.” In two-thirds of the transplant recipients, the fetal tissue took hold and seemed to establish a new network to produce the missing neurochemical dopamine.

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Citations of this work

Sham surgery: An ethical analysis.Franklin G. Miller - 2004 - Science and Engineering Ethics 10 (1):157-166.
Sham Surgery: An Ethical Analysis.Franklin G. Miller - 2003 - American Journal of Bioethics 3 (4):41-48.
Research Ethics and Misguided Moral Intuition.Franklin G. Miller - 2004 - Journal of Law, Medicine and Ethics 32 (1):111-116.

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