Journal of Medical Ethics 46 (3):172-177 (2020)

Authors
Abstract
BackgroundResearchers worry that patients in early-phase research experience unrealistic optimism about benefits and risks of participation. The standard measure of unrealistic optimism is the Comparative Risk/Benefit Assessment questionnaire, which asks people to estimate their chances of an outcome relative to others in similar situations. Such a comparative framework may not be a natural way for research participants to think about their chances.ObjectiveTo examine how people interpret questions measuring unrealistic optimism and how their interpretations are associated with their responses.MethodsUsing an early-phase cancer trial vignette, we administered the CRBA to 297 adults from the general public. They estimated their comparative chances of risk and benefit, then provided rationales for their estimates.ResultsFor both CRBA benefit and risk questions, about 50% of respondents chose 0, and 50% chose a non-0 response. Respondents’ rationales for their estimates showed that overall only about 40%–44% gave comparative rationales, indicating that they interpreted the CRBA as intended. 68.7% of respondents who gave the ‘correct’ 0 rating gave comparative rationales, whereas only 11.6% of respondents who gave non-0 ratings did so. A similar trend was seen for chances of risk.ConclusionResearch participants may not understand comparative benefit and risk questions as intended; attributions of unrealistic optimism may require additional evidence that the respondents’ estimates are intended to be comparative.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1136/medethics-2019-105377
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 71,231
Through your library

References found in this work BETA

View all 12 references / Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Two Concepts of Therapeutic Optimism.L. A. Jansen - 2011 - Journal of Medical Ethics 37 (9):563-566.
Costs and Benefits of Realism and Optimism.Lisa Bortolotti & Magdalena Antrobus - 2015 - Current Opinion in Psychiatry 28 (2):194-198.
Can Informed Consent to Research Be Adapted to Risk?Danielle Bromwich & Annette Rid - 2015 - Journal of Medical Ethics 41 (7):521-528.

Analytics

Added to PP index
2019-09-01

Total views
6 ( #1,137,139 of 2,518,239 )

Recent downloads (6 months)
1 ( #408,577 of 2,518,239 )

How can I increase my downloads?

Downloads

My notes