Abstract
Whereas experiments and computer simulations seem very different at first view because the former, but not the latter, involve interactions with material properties, we argue that this difference is not so important with respect to validation, as far as epistemologyEpistemology is concerned. Major differences remain nevertheless from the methodological point of view. We present and defend this distinction between epistemology and methodology. We illustrate this distinction and related claims by comparing how experiments and simulations are validated in evolutionary studies, a domain in which both experiments in the lab and computer simulations are relatively new but mutually reinforcing.