Causal explanation beyond the gene: manipulation and causality in epigenetics

Theoria 27 (2):153-174 (2012)
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Abstract

_This paper deals with the interrelationship between causal explanation and methodology in a relatively young discipline in biology: epigenetics. Based on cases from molecular and ecological epigenetics, I show that James Woodward’s interventionist account of causation captures essential features about how epigeneticists using highly diverse methods, i.e. laboratory experiments and purely observational studies, think about causal explanation. I argue that interventionism thus qualifies as a useful unifying explanatory approach when it comes to cross-methodological research efforts: It can act as a guiding rationale to link causal models in molecular biology with statistical models derived from observational data analysis and to identify test-criteria for reciprocal transparent studies in different fields of research, which is a shared issue across the sciences.___

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Jan Baedke
Ruhr-Universität Bochum

Citations of this work

The Ontic Account of Scientific Explanation.Carl F. Craver - 2014 - In Marie I. Kaiser, Oliver R. Scholz, Daniel Plenge & Andreas Hüttemann (eds.), Explanation in the Special Sciences: The Case of Biology and History. Springer Verlag. pp. 27-52.
High-Level Explanation and the Interventionist’s ‘Variables Problem’.L. R. Franklin-Hall - 2016 - British Journal for the Philosophy of Science 67 (2):553-577.
Causal graphs and biological mechanisms.Alexander Gebharter & Marie I. Kaiser - 2014 - In Marie I. Kaiser, Oliver Scholz, Daniel Plenge & Andreas Hüttemann (eds.), Explanation in the special sciences: The case of biology and history. Dordrecht: Springer. pp. 55-86.
Philosophy of Science in Germany, 1992–2012: Survey-Based Overview and Quantitative Analysis.Matthias Unterhuber, Alexander Gebharter & Gerhard Schurz - 2014 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 45 (1):71-160.

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