Explanation is commonly considered one of the central goals of science. Although computer simulations have become an important tool in many scientific areas, various philosophical concerns indicate that their explanatory power requires further scrutiny. We examine a case study in which atomistic simulations have been used to examine the factors responsible for the transport selectivity of certain channel proteins located at cell membranes. By elucidating how precisely atomistic simulations helped scientists draw inferences about the molecular system under investigation, we respond (...) to some concerns regarding their explanatory power. We argue that atomistic simulations can be tools for managing molecular complexity and for systematically assessing how the occurrence of the explanandum is sensitive to a range of factors. (shrink)

The predictive inadequacy of the social sciences is well documented, and philosophers have sought to diagnose it. This paper examines Brian Epstein’s recent diagnosis. He argues that the social sciences treat the social world as entirely composed of individual people. Instead, social scientists should recognize that material, non-individualistic entities determine the social world, as well. First, I argue that Epstein’s argument both begs the question against his opponents and is not sufficiently charitable. Second, I present doubts that his proposal will (...) improve predictive success for the social sciences, which I support with Edith Penrose’s resource-based theory of the firm. (shrink)

Agent-based models are increasingly important in social science research. They have two obvious apparent virtues: they can model complex macrosociological phenomena without strong assumptions about agents and without analytic solutions for models, and they seem to instantiate the methodological individualist program in a concrete way. We argue that the latter claim is false. After providing schematic accounts of ABM models and a first introduction to ways in which to characterize individualist explanations, we work through six conceptions of individualist explanations that (...) are decreasingly "less individualist" and argue that ABM-based explanations in the social sciences are not inevitably individualist in any of these senses. ABMs allow for explanatory relations among social entities and properties in the model environment and they are silent on what basic agents are, allowing social entities and properties to play basic explanatory roles. (shrink)