The classification frameworks for fault diagnosis of rolling element bearings in rotating machinery are mostly based on analysis in a single time-frequency domain, where sensitive features are not completely extracted. To solve this problem, a new fault diagnosis technique is proposed in the mixed domain, based on the crossover-mutation chaotic particle swarm optimization support vector machine. Firstly, fault features are generated using techniques in the time domain, the frequency domain, and the time-frequency domain. Secondly, the weighted maximum relevance minimum redundancy (...) algorithm is adopted to reduce the dimension of the feature set and to establish the representative feature set. Thirdly, a new crossover-mutation strategy is suggested to reduce the local minima in optimization, and an optimization disturbance is added. Finally, the support vector machine is optimized using the improved chaotic particle swarm to improve fault classification diagnosis. The effectiveness of the proposed new bearing fault diagnostic technique is verified by experimental tests under different bearing conditions. Test results showed that the bearing fault classification accuracy of CMCPSO-SVM in the mixed domain was much higher than those in a single feature domain. (shrink)