This paper situates Günther Anders’s diagnosis of a shift in the modes of human self-production from hermeneutic and educational practices to techno-scientific interventions in the broader context of observations concerning posthumanism and biopolitics. It proposes to reframe the problem of human self-production within the philosophy of media and traces a common anti-hermeneutic trajectory to which both technoscientific transhumanism and certain strands of posthumanism belong, insofar as they are based on an ontology that exclusively considers causally effective agency. With Anders and (...) Martin Heidegger it is argued that such a focus on agency neglects the dimension of meaning that irreducibly guides technoscientific interventions. The paper claims that, with regard to the escalating dynamics both of human enhancement and of the Anthropocene, neither a truly critical theoretical stance nor a practical subversion is possible without taking the horizons of meaning into account that drive these dynamics. The last section sketches an outline of the complex interrelations of humans, technologies and meaning that cannot be mapped in terms of causally effective agency. (shrink)