Math difficulties manifest across various domain-specific and domain-general abilities. However, the existing cognitive profile of MD is incomplete and thus not applicable in typical settings such as schools or clinics. So far, no review has applied inclusion criteria according to DSM or ICD, summarized domain-specific abilities or examined the validity of response time scores for MD identification. Based upon stringent clinical criteria, the current meta-analysis included 34 studies which compared cognitive performances of a group with MD and a group without (...) MD. Criteria according to DSM and ICD were applied to identify MD. Effect sizes for 22 abilities were estimated and separated by their level and type of scoring. A cognitive profile of MD was identified, characterized by distinct weaknesses in: computation, number sense, and visual-spatial short-term storage [AC]. No particular strength was found. Severity of MD, group differences in reading performance and IQ did not significantly moderate the results. Further analyses revealed that effects are larger when dealing with numbers or number words than with quantities, MD is not accompanied by any weakness in abilities typically assigned to reading, and weaknesses in visual-spatial short-term storage emphasize the notion that number and space are interlinked. The need for high-quality studies investigating domain-general abilities is discussed. (shrink)