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  1. After Fifty Years, Why Are Protein X-ray Crystallographers Still in Business?Sandra D. Mitchell & Angela M. Gronenborn - 2015 - British Journal for the Philosophy of Science:axv051.
    It has long been held that the structure of a protein is determined solely by the interactions of the atoms in the sequence of amino acids of which it is composed, and thus the stable, biologically functional conformation should be predictable by ab initio or de novo methods. However, except for small proteins, ab initio predictions have not been successful. We explain why this is the case and argue that the relationship among the different methods, models, and representations of protein (...)
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  • The Ontology of Patterns in Empirical Data.James W. McAllister - 2010 - Philosophy of Science 77 (5):804-814.
    This article defends the following claims. First, for patterns exhibited in empirical data, there is no criterion on which to demarcate patterns that are physically significant and patterns that are not physically significant. I call a pattern physically significant if it corresponds to a structure in the world. Second, all patterns must be regarded as physically significant. Third, distinct patterns must be regarded as providing evidence for distinct structures in the world. Fourth, in consequence, the world must be conceived as (...)
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  • What distinguishes data from models?Sabina Leonelli - 2019 - European Journal for Philosophy of Science 9 (2):22.
    I propose a framework that explicates and distinguishes the epistemic roles of data and models within empirical inquiry through consideration of their use in scientific practice. After arguing that Suppes’ characterization of data models falls short in this respect, I discuss a case of data processing within exploratory research in plant phenotyping and use it to highlight the difference between practices aimed to make data usable as evidence and practices aimed to use data to represent a specific phenomenon. I then (...)
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  • What distinguishes data from models?Sabina Leonelli - 2019 - European Journal for Philosophy of Science 9 (2):22.
    I propose a framework that explicates and distinguishes the epistemic roles of data and models within empirical inquiry through consideration of their use in scientific practice. After arguing that Suppes’ characterization of data models falls short in this respect, I discuss a case of data processing within exploratory research in plant phenotyping and use it to highlight the difference between practices aimed to make data usable as evidence and practices aimed to use data to represent a specific phenomenon. I then (...)
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  • Models of’ versus ‘Models for.Julia Gouvea & Cynthia Passmore - 2017 - Science & Education 26 (1-2):49-63.
    The inclusion of the practice of “developing and using models” in the Framework for K-12 Science Education and in the Next Generation Science Standards provides an opportunity for educators to examine the role this practice plays in science and how it can be leveraged in a science classroom. Drawing on conceptions of models in the philosophy of science, we bring forward an agent-based account of models and discuss the implications of this view for enacting modeling in science classrooms. Models, according (...)
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  • How autism shows that symptoms, like psychiatric diagnoses, are 'constructed': methodological and epistemic consequences.Sam Fellowes - 2021 - Synthese 199 (1-2):4499-4522.
    Critics who are concerned over the epistemological status of psychiatric diagnoses often describe them as being constructed. In contrast, those critics usually see symptoms as relatively epistemologically unproblematic. In this paper I show that symptoms are also constructed. To do this I draw upon the demarcation between data and phenomena. I relate this distinction to psychiatry by portraying behaviour of individuals as data and symptoms as phenomena. I then draw upon philosophers who consider phenomena to be constructed to argue that (...)
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  • Arche-writing and data-production in theory-oriented scientific practice: the case of free-viewing as experimental system to test the temporal correlation hypothesis.Juan Felipe Espinosa Cristia, Carla Fardella & Juan Manuel Garrido Wainer - 2021 - History and Philosophy of the Life Sciences 43 (2):1-27.
    Data production in experimental sciences depends on localised experimental systems, but the epistemic properties of data transcend the contingencies of the processes that produce them. Philosophers often believe that experimental systems instantiate but do not produce the epistemic properties of data. In this paper, we argue that experimental systems' local functioning entails intrinsic capacities to produce the epistemic properties of data. We develop this idea by applying Derrida's model of arche-writing to study a case of theory-oriented experimental practice. Derrida's model (...)
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  • Autonomous Patterns and Scientific Realism.Katherine Brading - 2010 - Philosophy of Science 77 (5):827-839.
    Taking Bogen and Woodward's discussion of data and phenomena as his starting point, McAllister presents a challenge to scientific realism. I discuss this challenge and offer a suggestion for how the scientific realist could respond to both its epistemic and ontological aspects. In so doing, I urge that the scientific realist should not reject ontological pluralism from the start, but should seek to explore versions of scientific realism that leave open the possibility of certain kinds of pluralist ontology. I investigate (...)
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  • Structures in Real Theory Application: A Study in Feasible Epistemology.Robert H. C. Moir - 2013 - Dissertation, University of Western Ontario
    This thesis considers the following problem: What methods should the epistemology of science use to gain insight into the structure and behaviour of scientific knowledge and method in actual scientific practice? After arguing that the elucidation of epistemological and methodological phenomena in science requires a method that is rooted in formal methods, I consider two alternative methods for epistemology of science. One approach is the classical approaches of the syntactic and semantic views of theories. I show that typical approaches of (...)
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