The following text is an introduction to Ed Cohen’s book A Body Worth Defending: Immunity, Biopolitics and the Apotheosis of the Modern Body. Author investigates the way in which immunology influences the perception of both the human body, and political entities, demonstrating that contemporary conceptualizations of these phenomena exist in a double bind. The historical framework Cohen applies allows for tracing the history of the metaphor of immunity in politics and medicine.

In biology, the ‘ecological orientation' rests on a commitment to examining systems, and the conceptual challenge of defining that system now employs techniques and concepts adapted from diverse disciplines (i.e., systems philosophy, cybernetics, information theory, computer science) that are applied to biological simulations and model building. Immunology has joined these efforts, and the question posed here is whether the discipline will remain committed to its theoretical concerns framed by the notions of protecting an insular self, an entity demarcated from its (...) environment, or will shift its focus of interest to a wider context. An ecological perspective emphasizes the interchange between the organism and its environment, the processing of information, and the regulation arising from responses to this larger context. Moving from the first attempts at modeling the immune system as a closed network, immunologists have joined the general interest in systems analysis, and that move might portend a significant shift to an open, more holistic consideration of immune regulation. *Received December 2006; revised August 2007. †To contact the author, please write to: Center for Philosophy and History of Science, Boston University, 745 Commonwealth Ave., Boston, MA 02215; e-mail: [email protected]. (shrink)

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that (...) another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity. (shrink)

[Przekład] Tekst niniejszy jest wprowadzeniem do książki Eda Cohena A Body Worth Defending: Immunity, Biopolitics and the Apotheosis of the Modern Body. Autor bada, w jaki sposób immunologia wpływa na postrzeganie tak ciała ludzkiego, jak i bytów politycznych, ukazując współczesne konceptualizacje tych zjawisk jako wzajemnie od siebie zależne. Zastosowane ujęcie historyczne pozwala na prześledzenie historii metafory odporności w polityce i medycynie.

Immunologists use psychological and cognitive terms to describe and explain the behavior of our immune system. Do they use them metaphorically or literally? In this paper I show that on the grounds of some psychophysical assumptions, the uniqueness of each person as an individual organism necessarily corresponds to the singularity of each person as a psychological subject. On the basis of these assumptions, immunologists, irrespective of their various conceptual frames, are entitled to ascribe psychological and cognitive traits to our immune (...) system and its behavior. Immunologists are allowed to do so because each immune system of any higher, unique individual organism corresponds to psychological traits, which are ascribable only to persons, each of whom is a singular being. This correspondence is necessarily compatible with the psychophysical unity or inseparability. Furthermore, the psychological or cognitive traits pertain to the immune system require no consciousness. In the case of artificial immune systems, in contrast, the application of psychological or cognitive terms is only metaphorical, for each such system is not unique but it is duplicable or replicable. Only the immune system of unique individual organisms that as psychological subjects are singular beings—i.e. persons—can be subject, literally or non-metaphorically, to psychological and cognitive terms. (shrink)

[Przekład] W artykule dokonano przeglądu historiografii immunologii od 1999 roku, co w pewnym stopniu jest odpowiedzią na stanowisko takich historyków jak Thomas Söderqvist, którzy twierdzili, że to pole badawcze nie było wówczas dość rozwinięte (Söderqvist i Stillwell). Najpierw wskazano przeszłe i teraźniejsze problemy, które historiografia ma ze zdefiniowaniem immunologii, a następnie skomentowano ostatnie studia nad pojęciem immunologicznego „ja”. W dalszym toku przeglądu przeanalizowano i oceniono nowe publikacje poświęcone zróżnicowanym zagadnieniom immunologii oraz niektóre charakterystyczne oskarżenia formułowane wobec niedostatku pewnych dziedzin historii, (...) na przykład historii biograficznych i historii instytucji. W podsumowaniu przedstawiono konkurujące ze sobą kierunki, w których rozwinęła się historia immunologii, wychodząc poza wstępne, tymczasowe stadia uchwycone w poprzednim przeglądzie, i stając się wielogłosową, pluripotencjalną dyscypliną, podobną do przedmiotu jej badań. Pokazano też, że historia immunologii nadal rozwija się na wiele nowych i ekscytujących sposobów. (shrink)