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Stopping rules and data monitoring in clinical trials

In H. W. de Regt, S. Hartmann & S. Okasha (eds.), EPSA Philosophy of Science: Amsterdam 2009, The European Philosophy of Science Association Proceedings Vol. 1, 375-386. Springer. pp. 375--386 (2012)

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  1. Early stopping of RCTs: two potential issues for error statistics.Roger Stanev - 2015 - Synthese 192 (4):1089-1116.
    Error statistics is an important methodological view in philosophy of statistics and philosophy of science that can be applied to scientific experiments such as clinical trials. In this paper, I raise two potential issues for ES when it comes to guiding, and explaining early stopping of randomized controlled trials : ES provides limited guidance in cases of early unfavorable trends due to the possibility of trend reversal; ES is silent on how to prospectively control error rates in experiments requiring multiple (...)
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  • Optimization of Scientific Reasoning: a Data-Driven Approach.Vlasta Sikimić - 2019 - Dissertation,
    Scientific reasoning represents complex argumentation patterns that eventually lead to scientific discoveries. Social epistemology of science provides a perspective on the scientific community as a whole and on its collective knowledge acquisition. Different techniques have been employed with the goal of maximization of scientific knowledge on the group level. These techniques include formal models and computer simulations of scientific reasoning and interaction. Still, these models have tested mainly abstract hypothetical scenarios. The present thesis instead presents data-driven approaches in social epistemology (...)
     
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  • Environmental Ethics.Roberta L. Millstein - 2013 - In K. Kampourakis (ed.), The Philosophy of Biology: A Companion for Educators. Springer.
    A number of areas of biology raise questions about what is of value in the natural environment and how we ought to behave towards it: conservation biology, environmental science, and ecology, to name a few. Based on my experience teaching students from these and similar majors, I argue that the field of environmental ethics has much to teach these students. They come to me with pent-up questions and a feeling that more is needed to fully engage in their subjects, and (...)
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