In “Science as a Vocation,” Max Weber identifies a trajectory within modernity of increased rationalization, which results in a dangerous loss of meaning, a marginalization of religion, and a disenchanted view of the world. Weber’s misunderstanding of religion as premodern and “magical” results in his underestimating how religion can contribute to “re-enchanting” a field of knowledge, specifically medicine. This article proposes to turn to a theology of the Holy Spirit as “giver of life” for resources to “re-enchant” medicine. Re-enchantment does (...) not require returning to a magical view of the world but retrieving a real sense of God at work in the world, thereby enabling the health care worker and scientist to arrive at a deeper understanding of vocation. (shrink)