The purpose of this study is to understand the postmaterialistic paradigm of science in the context of a holistic worldview and evolutionary worldview processes. The cosmological model of Helena Blavatsky, who systematically introduced the symmetric structure of the universe in the form of a hierarchy of mutual-integrational structures of matter of different levels, from crude physical matter to the most subtle, spiritual substance, is the methodological basis of the holistic picture of the world. The unity of the system, according to (...) Blavatsky, is provided by the egregore of the Absolute, approximated by conceptual content to the Transcendent. Accordingly, the absolute foundation of the world is an egregore that emits energy of a higher level than traditional energy sources, limited to the physical picture of the world. The article substantiates the conceptual foundations of the postmaterialistic paradigm of science, based on the achievements of quantum physics, synergetics, eniology and the theory of physical vacuum. The principles of the postmaterialistic paradigm allowing to change radically the methods of energy use, applying the energy potential of the egregore for subtle, non-material matters of reality to upgrade the energy efficiency taking into account the axiological dominant, are explicated. (shrink)