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  1. The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidence.Mariusz Maziarz & Adrian Stencel - 2022 - History and Philosophy of the Life Sciences 44 (4):1-26.
    The current strategy of searching for an effective treatment for COVID-19 relies mainly on repurposing existing therapies developed to target other diseases. Conflicting results have emerged in regard to the efficacy of several tested compounds but later results were negative. The number of conducted and ongoing trials and the urgent need for a treatment pose the risk that false-positive results will be incorrectly interpreted as evidence for treatments’ efficacy and a ground for drug approval. Our purpose is twofold. First, we (...)
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  • Causal Pluralism in Medicine and its Implications for Clinical Practice.Mariusz Maziarz - forthcoming - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie:1-22.
    The existing philosophical views on what is the meaning of causality adequate to medicine are vastly divided. We approach this question and offer two arguments in favor of pluralism regarding concepts of causality. First, we analyze the three main types of research designs (randomized-controlled trials, observational epidemiology and laboratory research). We argue, using examples, that they allow for making causal conclusions that are best understood differently in each case (in agreement with a version of manipulationist, probabilistic and mechanistic definitions, respectively). (...)
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  • On evidence fiascos and judgments in COVID-19 policy.Stefano Canali & Saana Jukola - 2021 - History and Philosophy of the Life Sciences 43 (2):1-4.
    Calls for evidence-based approaches to COVID-19 have sparked up discussions on the use of evidence for policy. In this note, we expand these discussions: while the debate has mostly focused on the types of evidence to be used for policy, we argue that the assessment of judgments involved in data practices and evidence production should play a central role in evaluating policy.
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