The debate between emergentists and reductionists rests on the observation that in many situations, in which it seems desirable to work with a coherent and unified discourse, key predicates fall into different groups, such that pairs of members one taken from each group, cannot be co-predicated of some common subject. Must we settle for ‘island’ discourses in science and human affairs or is some route to a unified discourse still open? To make progress towards resolving the issue the conditions under (...) which such segregations of predicates seem inexorable must be brought out. The distinction between determinable and determinate properties throws light on some aspects of this problem. Bohr’s concept of complementarity, when combined with Gibson’s idea of an affordances as a special class of dispositional properties is helpful. Several seeming problems melt away, for example, how it is possible for a group of notes to become hearable as a melody. The mind-body problem and the viability of the project of reducing biology to chemistry and physics are two issues that are more difficult to deal with. Are mental phenomena, such as feelings and memories emergent from material systems or are they actually material properties themselves? Are the attributes of living beings emergent from certain accidental but long running collocations of chemical reactions, or are they nothing but chemical phenomena? If emergent, in what way are they distinctive from that from which they emerge? (shrink)

Understood in their historical context, current debates about psychiatric classification, prompted by the publication of the DSM-5, open up new opportunities for improved translational research in psychiatry. In this paper, we draw lessons for translational research from three time slices of 20th century psychiatry. From the first time slice, 1913 and the publication of Jaspers’ General Psychopathology, the lesson is that translational research in psychiatry requires a pluralistic approach encompassing equally the sciences of mind (including the social sciences) and of (...) brain. From the second time slice, 1953 and a conference in New York from which our present symptom-based classifications are derived, the lesson is that, while reliability remains the basis of psychiatry as an observational science, validity too is essential to effective translation. From the third time slice, 1997 and a conference on psychiatric classification in Dallas that brought together patients and carers with researchers and clinicians, the lesson is that we need to build further on collaborative models of research combining expertise-by-training with expertise-by-experience. This is important if we are to meet the specific challenges to translation presented by the complexity of the concept of mental disorder, particularly as reflected in the diversity of desired treatment outcomes. Taken together, these three lessons – a pluralistic approach, reliability and validity, and closer collaboration – provide an emerging framework for more effective translation of research into practice in 21st century psychiatry. (shrink)

This chapter identifies and explores a series of challenges raised by the clinical concept of delusion for theories which conceive autonomy as an agency rather than a status concept. The first challenge is to address the autonomy-impairing nature of delusions consistently with their role as grounds for full legal and ethical excuse, on the one hand, and psychopathological significance as key symptoms of psychoses, on the other. The second challenge is to take into account the full logical range of delusions, (...) which may take the form of true or false factual beliefs, positive or negative evaluations, as well as the paradoxical delusion of mental illness. The third and final challenge is to make room for non-pathological or, autonomy-preserving delusions and to offer a credible way of distinguishing between these and pathological or, autonomy-impairing delusions. By setting out these challenges, we are able to, firstly, distinguish between two separate conceptions of objectivity that may be at work in existing accounts of delusions and, secondly, to put a spotlight on an elusive yet inescapable notion of agential success that underlies our thinking about autonomy as well as mental disorder. (shrink)