In this article, I describe a multidisciplinary project at the interface of philosophy, science, and theology. The project is the product of an ongoing collaboration between the author and Christopher Southgate, to whom this special issue of Zygon is dedicated. At the philosophical core of the project is a development of C. S. Peirce's semiotics (theory of signs). The scientific branch of the project involves the application of semiotic theory to the problem of the origin of life, and to questions (...) about human evolution and human distinctiveness. The theological branch of the project involves the articulation of a semiotic approach to the Christian concepts of Incarnation and Trinity, and to the ideas of vestiges of the Trinity in creation and of participation in God's life. The purpose of this paper is to analyze the project in terms of Robert John Russell's model of ‘creative mutual interaction’ between science and theology. (shrink)