Skeptical invariantism does not account for the intuitive connections between knowledge, assertion, and practical reasoning and this constitutes a significant problem for the position because it does not save corresponding epistemic appearances (cf. Hawthorne (2004:131-5)). Moreover, it is an attraction of fallibilist over infallibilist-skeptical views that they can easily account for the epistemic appearances about the connections between knowledge, assertion, and practical reasoning (cf. Williamson (2000:249-255)). Call this argument ‘the argument from the knowledge norm’. I motivate and develop a Humean, (...) pragmatist strategy for a skeptical response to ‘the argument from the knowledge norm’. Afterwards I outline a ‘toy’ version of pragmatic skepticism that can implement the strategy and save our everyday practice of assertion and practical reasoning. To this effect, I distinguish between assertibility conditions and truth conditions for ‘know’ and suggest that while assertibility conditions are pragmatic conditions sensitive to practical exigencies, truth conditions are semantic conditions sensitive only to truth. I briefly respond to three objections and conclude that pragmatic skepticism is resourceful enough to save our everyday practice of (fallibilist) assertion and practical reasoning and, hence, pay some due respect to corresponding epistemic appearances. (shrink)