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  1. Hypothesis-driven science in large-scale studies: the case of GWAS.Sumana Sharma & James Read - 2021 - Biology and Philosophy 36 (5):1-21.
    It is now well-appreciated by philosophers that contemporary large-scale ‘-omics’ studies in biology stand in non-trivial relationships to more orthodox hypothesis-driven approaches. These relationships have been clarified by Ratti (2015); however, there remains much more to be said regarding how an important field of genomics cited in that work—‘genome-wide association studies’ (GWAS)—fits into this framework. In the present article, we propose a revision to Ratti’s framework more suited to studies such as GWAS. In the process of doing so, we introduce (...)
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  • The predictive reframing of machine learning applications: good predictions and bad measurements.Alexander Martin Mussgnug - 2022 - European Journal for Philosophy of Science 12 (3):1-21.
    Supervised machine learning has found its way into ever more areas of scientific inquiry, where the outcomes of supervised machine learning applications are almost universally classified as predictions. I argue that what researchers often present as a mere terminological particularity of the field involves the consequential transformation of tasks as diverse as classification, measurement, or image segmentation into prediction problems. Focusing on the case of machine-learning enabled poverty prediction, I explore how reframing a measurement problem as a prediction task alters (...)
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  • Data and Model Operations in Computational Sciences: The Examples of Computational Embryology and Epidemiology.Fabrizio Li Vigni - 2022 - Perspectives on Science 30 (4):696-731.
    Computer models and simulations have become, since the 1960s, an essential instrument for scientific inquiry and political decision making in several fields, from climate to life and social sciences. Philosophical reflection has mainly focused on the ontological status of the computational modeling, on its epistemological validity and on the research practices it entails. But in computational sciences, the work on models and simulations are only two steps of a longer and richer process where operations on data are as important as, (...)
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  • Values and inductive risk in machine learning modelling: the case of binary classification models.Koray Karaca - 2021 - European Journal for Philosophy of Science 11 (4):1-27.
    I examine the construction and evaluation of machine learning binary classification models. These models are increasingly used for societal applications such as classifying patients into two categories according to the presence or absence of a certain disease like cancer and heart disease. I argue that the construction of ML classification models involves an optimisation process aiming at the minimization of the inductive risk associated with the intended uses of these models. I also argue that the construction of these models is (...)
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  • A pragmatic approach to scientific change: transfer, alignment, influence.Stefano Canali - 2022 - European Journal for Philosophy of Science 12 (3):1-25.
    I propose an approach that expands philosophical views of scientific change, on the basis of an analysis of contemporary biomedical research and recent developments in the philosophy of scientific change. Focusing on the establishment of the exposome in epidemiology as a case study and the role of data as a context for contrasting views on change, I discuss change at conceptual, methodological, material, and social levels of biomedical epistemology. Available models of change provide key resources to discuss this type of (...)
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