We frame the question of what kind of subjective experience a brain simulation would have in contrast to a biological brain. We discuss the brain prosthesis thought experiment. Then, we identify finer questions relating to the original inquiry, and set out to answer them moving forward from both a general physicalist perspective, and pan-experientialism. We propose that the brain simulation is likely to have subjective experience, however, it may differ significantly from human experience. Additionally, we discuss the relevance of quantum (...) properties, digital physics, theory of relativity, and information theory to the question. (shrink)