Philosophical discussions have critically analysed the methodological pitfalls and epistemological implications of evidence assessment in medicine, however they have mainly focused on evidence of treatment efficacy. Most of this work is devoted to statistical methods of causal inference with a special attention to the privileged role assigned to randomized controlled trials (RCTs) in evidence based medicine. Regardless of whether the RCT’s privilege holds for efficacy assessment, it is nevertheless important to make a distinction between causal inference of intended and unintended (...) effects, in that the unknowns at stake are heterogonous in the two contexts. However, although “lower level” evidence is increasingly acknowledged to be a valid source of information contributory to assessing the risk profile of medications on theoretical or empirical grounds, current practices have difficulty in assigning a precise epistemic status to this kind of evidence because they are more or less implicitly parasitic on the (statistical) methods developed to test drug efficacy. My thesis is that (1) “lower level” evidence is justified on distinct grounds and at different conditions depending on the different epistemologies which one wishes to endorse, in that each impose different constraints on the methods we adopt to collect and evaluate evidence; (2) such constraints ought to be understood to be different in the case of evidence for risk versus benefit assessment for a series of reasons which I will illustrate on the basis of the recent debate on the causal association between acetaminophen (a.k.a. paracetamol) and asthma. (shrink)

Scientists confronted with multiple explanatory hypotheses as a result of their abductive inferences, generally want to reason further on the different hypotheses one by one. This paper presents a modal adaptive logic MLA s that enables us to model abduction in such a way that the different explanatory hypotheses can be derived individually. This modelling is illustrated with a case study on the different hypotheses on the origin of the Moon.

_Abduction of generalizations_ is the process in which explanatory hypotheses are formed for an observed, yet puzzling generalization such as ``pineapples taste sweet" or ``rainbows appear when the sun breaks through the rain". This phenomenon has received little attention in formal logic and philosophy of science. The current paper remedies this lacuna by first giving an overview of some general characteristics of this process, elaborating on its ubiquity in scientific and daily life reasoning. Second, the adaptive logic $\LAG$ is presented (...) to explicate this process formally. (shrink)

We propose a logic of abduction that (i) provides an appropriate formalization of the explanatory conditional, and that (ii) captures the defeasible nature of abductive inference. For (i), we argue that explanatory conditionals are non-classical, and rely on Brian Chellas’s work on conditional logics for providing an alternative formalization of the explanatory conditional. For (ii), we make use of the adaptive logics framework for modeling defeasible reasoning. We show how our proposal allows for a more natural reading of explanatory relations, (...) and how it overcomes problems faced by other systems in the literature. (shrink)