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  1. Cluster Randomized Trials:Another Look.Ruth Macklin - 2014 - Hastings Center Report 44 (1):37-43.
  • Informed Consent and Community Engagement in Open Field Research: Lessons for Gene Drive Science.Jerome Amir Singh - 2019 - BMC Medical Ethics 20 (1):54.
    The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene drive constructs to reduce or suppress mosquito populations to levels that do not support disease transmission. Despite this prospect, social resistance to genetically modified organisms remains high. Gene drive open field research thus raises important questions regarding what is owed to those who may not consent to such research, or those could be affected by the proposed research, but whose consent is not solicited. (...)
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  • Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside.Sarah Jl Edwards - 2013 - American Journal of Bioethics 13 (9):3-14.
    Clinical research under the usual regulatory constraints may be difficult or even impossible in a public health emergency. Regulators must seek to strike a good balance in granting as wide therapeutic access to new drugs as possible at the same time as gathering sound evidence of safety and effectiveness. To inform current policy, I reexamine the philosophical rationale for restricting new medicines to clinical trials, at any stage and for any population of patients (which resides in the precautionary principle), to (...)
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